Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2279495..2280234 Replicon chromosome
Accession NZ_CP071017
Organism Enterobacter hormaechei strain RIVM_C019072

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag JQL75_RS10990 Protein ID WP_022648141.1
Coordinates 2279495..2279980 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag JQL75_RS10995 Protein ID WP_003857131.1
Coordinates 2279968..2280234 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL75_RS10960 2275544..2275804 + 261 WP_206215745.1 SDR family NAD(P)-dependent oxidoreductase -
JQL75_RS10970 2276862..2277533 + 672 WP_206215746.1 SDR family oxidoreductase -
JQL75_RS10975 2278182..2278463 + 282 Protein_2138 DUF4225 domain-containing protein -
JQL75_RS10980 2278438..2278767 - 330 WP_022648139.1 hypothetical protein -
JQL75_RS10985 2278900..2279469 + 570 WP_022648140.1 hypothetical protein -
JQL75_RS10990 2279495..2279980 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
JQL75_RS10995 2279968..2280234 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
JQL75_RS11000 2280298..2281227 - 930 WP_022648142.1 LysR family transcriptional regulator -
JQL75_RS11005 2281357..2282745 + 1389 WP_022648143.1 MFS transporter -
JQL75_RS11010 2282724..2283281 - 558 WP_022648144.1 OmpH family outer membrane protein -
JQL75_RS11015 2283402..2284538 - 1137 WP_022648145.1 type 1 fimbrial protein -
JQL75_RS11020 2284562..2285086 - 525 WP_087878309.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2255403..2280234 24831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T195036 WP_022648141.1 NZ_CP071017:c2279980-2279495 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T195036 NZ_CP094289:c3335007-3334594 [Georgenia sp. TF02-10]
GTGATCCTTGTTGACACCTCCGCATGGGTCGAGCTCGACCGAGCGACGGGCAGCCCGGTGCACCACCGATTACGCGACCT
TGTCGCGGCCGGTGATGAGCTGGCCGTGACCGAACCGGTGATCATGGAGGTGCTGGCCGGGGCCCGGGACGACGCGCGGG
AGACCAGCCTCCGCCGCCTCCTCTTGCGGTTCCAGCTGCTCAGCGTCGATCCCACCGGAGACTTCGAGGCCGCGGCGCGC
ATCTACCGCCGGTGCCGGGCGGTGGGGGTGACACCGAGAGGGATTATTGACTGCCTGATCGTCGTCGTCGCCTGGCGGTG
GGGCGCCGCTCTGCTGGCCCAGGACGTCGACCTCGTGCGGGTGGCGGGAGTTCTGGACGTCCCGCTGGACCCGGCCACGC
CCGGAGCCCGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT195036 WP_003857131.1 NZ_CP071017:c2280234-2279968 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT195036 NZ_CP094289:c3335216-3335004 [Georgenia sp. TF02-10]
ATGACCAGGATCAGGACCAACATCGAGATCGAGGACACCTATCTCGAGATCGTGATGAAGCGATACCTGCTCCGGACGAA
GACGGAAGCAGTCGACCTCGCGCTCCGTCATCTCGCCGGTCAGCCGATGACACGCGAGGAGGCGCTCGCGATGGAGGGGG
CGAAGGCGATCGGGGAGGTCCCCACGGACGTGCCGCCCCGTGGTGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References