Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2279487..2280226 Replicon chromosome
Accession NZ_CP071015
Organism Enterobacter hormaechei strain RIVM_C019181

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag JQL71_RS10985 Protein ID WP_022648141.1
Coordinates 2279487..2279972 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag JQL71_RS10990 Protein ID WP_003857131.1
Coordinates 2279960..2280226 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL71_RS10955 2275536..2275796 + 261 WP_206215745.1 SDR family NAD(P)-dependent oxidoreductase -
JQL71_RS10965 2276854..2277525 + 672 WP_206215746.1 SDR family oxidoreductase -
JQL71_RS10970 2278174..2278455 + 282 Protein_2137 DUF4225 domain-containing protein -
JQL71_RS10975 2278430..2278759 - 330 WP_022648139.1 hypothetical protein -
JQL71_RS10980 2278892..2279461 + 570 WP_022648140.1 hypothetical protein -
JQL71_RS10985 2279487..2279972 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
JQL71_RS10990 2279960..2280226 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
JQL71_RS10995 2280290..2281219 - 930 WP_022648142.1 LysR family transcriptional regulator -
JQL71_RS11000 2281349..2282737 + 1389 WP_022648143.1 MFS transporter -
JQL71_RS11005 2282716..2283273 - 558 WP_022648144.1 OmpH family outer membrane protein -
JQL71_RS11010 2283394..2284530 - 1137 WP_022648145.1 type 1 fimbrial protein -
JQL71_RS11015 2284554..2285078 - 525 WP_087878309.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2255395..2283273 27878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T195020 WP_022648141.1 NZ_CP071015:c2279972-2279487 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T195020 NZ_CP094280:864724-865134 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGTAGCGGTATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT195020 WP_003857131.1 NZ_CP071015:c2280226-2279960 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT195020 NZ_CP094280:864477-864743 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGATAAGCGTCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGTAAGCCGGCAGATGCGCAACTACAACGGATGATAAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References