Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3454049..3454788 Replicon chromosome
Accession NZ_CP071011
Organism Enterobacter hormaechei strain RIVM_C034177

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag JQL78_RS16395 Protein ID WP_022649088.1
Coordinates 3454408..3454788 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag JQL78_RS16390 Protein ID WP_022649087.1
Coordinates 3454049..3454375 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL78_RS16375 3449943..3452603 - 2661 WP_022649084.1 hypothetical protein -
JQL78_RS16380 3453137..3453556 + 420 Protein_3197 antirestriction protein -
JQL78_RS16385 3453571..3454038 + 468 WP_022649086.1 DNA repair protein RadC -
JQL78_RS16390 3454049..3454375 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JQL78_RS16395 3454408..3454788 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
JQL78_RS16400 3454785..3455012 + 228 WP_022649089.1 hypothetical protein -
JQL78_RS16405 3455404..3455697 + 294 WP_022649090.1 hypothetical protein -
JQL78_RS16410 3456041..3457357 - 1317 WP_206215736.1 amidase -
JQL78_RS16415 3457412..3458707 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3429717..3455697 25980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T194997 WP_022649088.1 NZ_CP071011:3454408-3454788 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T194997 NZ_CP094269:c4526660-4526349 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT194997 WP_022649087.1 NZ_CP071011:3454049-3454375 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT194997 NZ_CP094269:c4526348-4526058 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References