Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3734342..3734999 Replicon chromosome
Accession NZ_CP071009
Organism Enterobacter hormaechei strain RIVM_C034192

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag JQL73_RS17745 Protein ID WP_022649305.1
Coordinates 3734342..3734752 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag JQL73_RS17750 Protein ID WP_003863437.1
Coordinates 3734733..3734999 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL73_RS17725 3730340..3732073 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
JQL73_RS17730 3732079..3732792 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JQL73_RS17735 3732821..3733717 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
JQL73_RS17740 3733819..3734340 + 522 WP_015571793.1 flavodoxin FldB -
JQL73_RS17745 3734342..3734752 - 411 WP_022649305.1 protein YgfX Toxin
JQL73_RS17750 3734733..3734999 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
JQL73_RS17755 3735294..3736274 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
JQL73_RS17760 3736798..3737457 - 660 WP_022649307.1 hemolysin III family protein -
JQL73_RS17765 3737724..3738455 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T194982 WP_022649305.1 NZ_CP071009:c3734752-3734342 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T194982 NZ_CP094264:c1923913-1923653 [Streptomyces sp. MRC013]
ATGTCGATCAGCGCCAGCAAGGCCCGGGACGAGCTGTTCCCGCTGATAGAGAAGGTCAACAACGACCACGAGCCGGTGCA
CATCACCTCCCGCAAAGGGAACGCCTACCTGATCGCCGAGGACGACTTCCGGGGGTGGCAGGAGACCGCCTACCTGCTCC
GCTCACCGGCCAACGCCCGCGTGCTGATGGACTCCATCGCGGAACTGGACGCGGGGGAGGGGCAGATCGGGGACCTCGTG
GACACGGGGGGCGACGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT194982 WP_003863437.1 NZ_CP071009:c3734999-3734733 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT194982 NZ_CP094264:c1923656-1923396 [Streptomyces sp. MRC013]
GTGAAGAAGCTGTTCTCCTCCACGGCCTGGGAGCAGTACGCGCACTGGGCGACCGCCGACCCGAAGATCCTCAAGAAGAC
CAACCGCCTCATCAAGGACATCGAGCGCACACCGTTCGAGGGCATGGGCAAGCCCGAACCGCTCAAGGGCAATTTGTCCG
GTTGGTGGTCGCGCCGCATCACCGACGAGCACCGCCTCGTGTACCGCGCGCACGACGACCGCGTCGAGATCGCCCTGGCC
CGGTACCACTACGGGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References