Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3454051..3454790 Replicon chromosome
Accession NZ_CP071009
Organism Enterobacter hormaechei strain RIVM_C034192

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag JQL73_RS16395 Protein ID WP_022649088.1
Coordinates 3454410..3454790 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag JQL73_RS16390 Protein ID WP_022649087.1
Coordinates 3454051..3454377 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL73_RS16375 3449945..3452605 - 2661 WP_022649084.1 hypothetical protein -
JQL73_RS16380 3453139..3453558 + 420 Protein_3197 antirestriction protein -
JQL73_RS16385 3453573..3454040 + 468 WP_022649086.1 DNA repair protein RadC -
JQL73_RS16390 3454051..3454377 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JQL73_RS16395 3454410..3454790 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
JQL73_RS16400 3454787..3455014 + 228 WP_022649089.1 hypothetical protein -
JQL73_RS16405 3455406..3455699 + 294 WP_022649090.1 hypothetical protein -
JQL73_RS16410 3456043..3457359 - 1317 WP_206215736.1 amidase -
JQL73_RS16415 3457414..3458709 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3418040..3455699 37659


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T194981 WP_022649088.1 NZ_CP071009:3454410-3454790 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T194981 NZ_CP094264:c1923656-1923396 [Streptomyces sp. MRC013]
GTGAAGAAGCTGTTCTCCTCCACGGCCTGGGAGCAGTACGCGCACTGGGCGACCGCCGACCCGAAGATCCTCAAGAAGAC
CAACCGCCTCATCAAGGACATCGAGCGCACACCGTTCGAGGGCATGGGCAAGCCCGAACCGCTCAAGGGCAATTTGTCCG
GTTGGTGGTCGCGCCGCATCACCGACGAGCACCGCCTCGTGTACCGCGCGCACGACGACCGCGTCGAGATCGCCCTGGCC
CGGTACCACTACGGGGCTTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT194981 WP_022649087.1 NZ_CP071009:3454051-3454377 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT194981 NZ_CP094264:c1923913-1923653 [Streptomyces sp. MRC013]
ATGTCGATCAGCGCCAGCAAGGCCCGGGACGAGCTGTTCCCGCTGATAGAGAAGGTCAACAACGACCACGAGCCGGTGCA
CATCACCTCCCGCAAAGGGAACGCCTACCTGATCGCCGAGGACGACTTCCGGGGGTGGCAGGAGACCGCCTACCTGCTCC
GCTCACCGGCCAACGCCCGCGTGCTGATGGACTCCATCGCGGAACTGGACGCGGGGGAGGGGCAGATCGGGGACCTCGTG
GACACGGGGGGCGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References