Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4479545..4481238 Replicon chromosome
Accession NZ_CP071007
Organism Pseudomonas sp. SORT22

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag JYG36_RS20465 Protein ID WP_213602120.1
Coordinates 4479545..4480414 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1H1EW67
Locus tag JYG36_RS20470 Protein ID WP_045193445.1
Coordinates 4480411..4481238 (+) Length 276 a.a.

Genomic Context

JYG36_RS20440JYG36_RS20445JYG36_RS20450JYG36_RS20455JYG36_RS20460JYG36_RS20465JYG36_RS20470JYG36_RS20475JYG36_RS20480JYG36_RS20485JYG36_RS20490
Location: 4475542..4476378 (837 bp)
Type: Others
Protein ID: WP_045193440.1
Location: 4476418..4477416 (999 bp)
Type: Others
Protein ID: WP_213602118.1
Location: 4477446..4478222 (777 bp)
Type: Others
Protein ID: WP_045193442.1
Location: 4478222..4478986 (765 bp)
Type: Others
Protein ID: WP_093387658.1
Location: 4479001..4479540 (540 bp)
Type: Others
Protein ID: WP_093386119.1
Location: 4479545..4480414 (870 bp)
Type: Toxin
Protein ID: WP_213602120.1
Location: 4480411..4481238 (828 bp)
Type: Antitoxin
Protein ID: WP_045193445.1
Location: 4481240..4482040 (801 bp)
Type: Others
Protein ID: WP_213602122.1
Location: 4482033..4483715 (1683 bp)
Type: Others
Protein ID: WP_213602124.1
Location: 4483726..4484529 (804 bp)
Type: Others
Protein ID: WP_045193450.1
Location: 4484540..4486030 (1491 bp)
Type: Others
Protein ID: WP_213602126.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JYG36_RS20440 (JYG36_20440)4475542..4476378+837WP_045193440.1ABC transporter ATP-binding protein-
JYG36_RS20445 (JYG36_20445)4476418..4477416+999WP_213602118.1ABC transporter substrate-binding protein-
JYG36_RS20450 (JYG36_20450)4477446..4478222+777WP_045193442.1ABC transporter permease-
JYG36_RS20455 (JYG36_20455)4478222..4478986+765WP_093387658.1SDR family oxidoreductase-
JYG36_RS20460 (JYG36_20460)4479001..4479540+540WP_093386119.1cupin domain-containing protein-
JYG36_RS20465 (JYG36_20465)4479545..4480414+870WP_213602120.1alpha/beta fold hydrolaseToxin
JYG36_RS20470 (JYG36_20470)4480411..4481238+828WP_045193445.1IclR family transcriptional regulatorAntitoxin
JYG36_RS20475 (JYG36_20475)4481240..4482040+801WP_213602122.1SDR family oxidoreductase-
JYG36_RS20480 (JYG36_20480)4482033..4483715+1683WP_213602124.1thiamine pyrophosphate-binding protein-
JYG36_RS20485 (JYG36_20485)4483726..4484529+804WP_045193450.1aspartate dehydrogenase-
JYG36_RS20490 (JYG36_20490)4484540..4486030+1491WP_213602126.1aldehyde dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(43-274)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30626.92 Da        Isoelectric Point: 6.8725

>T194968 WP_213602120.1 NZ_CP071007:4479545-4480414 [Pseudomonas sp. SORT22]
MLHATDHSLAGLAAQLQQRFPQRLVQLASGAQAIREAGHGPAIVLLHGIGSGAASWLQVALQLSQHARVIAWDAPGYGDS
SPLANPAPQAADYARRLRHLLDALQIDDCLLVGHSLGALSAAALAQQQPQRVRRLVLISPARGYGDPARAEQAQQVRNQR
LHNLEQLGIAQMANQRSAHMLSPAASSEARAWVQWNMARLLPQGYRQAIELLCGDDLLRYAALAVPCEVHCGAADSITLP
EDCQALAKALGAAFALIAEAGHASPIEQPEAVASLLARALEESLTGTAL

Download         Length: 870 bp

>T194968 NZ_CP094240:c3079598-3078300 [Comamonas sp. 7D-2evo2]
ATGACGCATGAACTCGAAGTCTGGCTGTTTGAGCGGCGCGTGGGAAGCCTGTCGCTGGTGCATGGGCGGCTGAGCTTTGC
CTATGCGACCGAATGGTTGGCGCTGCCGCAGGCCACGGCTTTATCGCAGTCGCTGCCGCTGCAGGCTGAGCCCTTTGGCG
ATCACCAGACCCGGCCATTCTTTGCCGGTCTGCTGCCCGAGGGGCAGATGCGACGCCTGATTGCCCAGCAATTTCAGGTG
TCGGGCCAGAACGATTTTGCGTTGCTGGACCATATTGGAGGCGAATGCGCGGGGGCCGTGACCTTTCTGGAACCAGGGCA
AGCCTTGCCGCAGACTGACGGGGCTGGGGCGACCAGGGAATCGGGTGATGTGGAGTGGCTCAGCGATCAAAAGCTGCTCG
CCTTGCTGGACGAGCTGCCGCGCCGCCCCATGCTGGCGGGAGATGACGGGCTGCGGCTGTCGCTGGCCGGGGCGCAGGAC
AAGCTGCCCGTGGTGGTGGACGACAGCATTCCGGGCGCAGTGCGTATCGGTCTGCCGCGCAACGGCGCTCCCAGCTCGCA
TATCTTGAAGCCCGCCATCCATGCGGTGGAGGACAGCGTAGCCAACGAAGGCTTTTGCATGCTGCTGGCCCAGGTCATGG
GGCTGCGGCCTGCCAATGCCCGAATCCAGAGCGTGCTGGGCCGCTCGTTTTTGCTGGTGAAGCGCTATGACCGGGTGCTG
AAGGACGATGCGCAGGGCCAAGCGCAGCTGCAACGTCTGCACCAGGAAGACTTTTGCCAGGCGCTGGGCGTGGTGCCCGA
GCTGAAGTACCAGAACGAGGGCGGGCCAGGCCTGGCCCAATGCTTTGCCTTGGCGCGCAGCGTGACCCGCCCCAGCGCGC
CGCAGGTTCTGCGGCTGCTGGATGGGGTGATCTTCAATGCCCTGATCGGCAACCATGACGCACATGGCAAGAATTTCTCG
CTGCTTTATGGAGGAAGGGCGCCTGTGCTGGCACCGTTCTACGACCTGCTGGCTACGGCGATTTACCCCCAGCTGACGCC
CAAGATGGCAATGAAGATTGGCAGCAAATACAAGTTCAGCGAGCTGGAGGCCAGGCACTGGGAGCAGTTTGCGGAAGAAG
CAGGCCTTGCCAAGGCGGCGACGAGCAAGCGTTTGCAGCAGCTGGCGAACGAACTACCCGCTGCCGCGCGCAAGCTGCAG
GCCGCGCCACCGCATGGTTTTGCGGGCAATGCCGTGGTGACGCAGATCGTGCAGCTGATAGAGCAGCGCTGCGCCTTGAC
GCTGAGGCGCTTGGCCTGA

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30416.81 Da        Isoelectric Point: 6.3865

>AT194968 WP_045193445.1 NZ_CP071007:4480411-4481238 [Pseudomonas sp. SORT22]
MNDSDLLKDNQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSPCTPKTVLELFDLVQSDRQRGYVSGEGFFESSISTIAAPVRDHSGRVVAAMGVTIPTVQVAHINF
DGLLGHVRGSADELSRLLNYTPNAGSGRVTALMRD

Download         Length: 828 bp

>AT194968 NZ_CP094240:c3079869-3079588 [Comamonas sp. 7D-2evo2]
ATGTCCACCATCCACACCACCGACCAACTGGGCACGGCCCTGCGCATCGCCCGCAAACAACTGGGGCTGACCCAGCCGCA
GCTTGCCTTGGCCGCAGGCGTGGGCACGCGGTTTATTGTAGATCTGGAGTCGGGCAAGCCCACGGTGCGGCTGGAGCATG
TGCTGCGGGTGATCGATGCGCTGGGGGGAGAGTTGCAGTTGGGCGGCTTGCCGGAAGCGGCGCATGAAGACGGGGCAGGC
CAGGCTGCCGCAGCAACGGAGGGCGCAGACCATGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1H1EW67

References