Detailed information of TA system TA194968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 4479545..4481238
• Replicon: chromosome
• Accession: NZ_CP071007
• Organism: Pseudomonas sp. SORT22

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: JYG36_RS20465
• Protein ID: WP_213602120.1
• Coordinates: 4479545..4480414 (+)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1H1EW67
• Locus tag: JYG36_RS20470
• Protein ID: WP_045193445.1
• Coordinates: 4480411..4481238 (+)
• Length: 276 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYG36_RS20440 (JYG36_20440)	4475542..4476378	+	837	WP_045193440.1	ABC transporter ATP-binding protein	-
JYG36_RS20445 (JYG36_20445)	4476418..4477416	+	999	WP_213602118.1	ABC transporter substrate-binding protein	-
JYG36_RS20450 (JYG36_20450)	4477446..4478222	+	777	WP_045193442.1	ABC transporter permease	-
JYG36_RS20455 (JYG36_20455)	4478222..4478986	+	765	WP_093387658.1	SDR family oxidoreductase	-
JYG36_RS20460 (JYG36_20460)	4479001..4479540	+	540	WP_093386119.1	cupin domain-containing protein	-
JYG36_RS20465 (JYG36_20465)	4479545..4480414	+	870	WP_213602120.1	alpha/beta fold hydrolase	Toxin
JYG36_RS20470 (JYG36_20470)	4480411..4481238	+	828	WP_045193445.1	IclR family transcriptional regulator	Antitoxin
JYG36_RS20475 (JYG36_20475)	4481240..4482040	+	801	WP_213602122.1	SDR family oxidoreductase	-
JYG36_RS20480 (JYG36_20480)	4482033..4483715	+	1683	WP_213602124.1	thiamine pyrophosphate-binding protein	-
JYG36_RS20485 (JYG36_20485)	4483726..4484529	+	804	WP_045193450.1	aspartate dehydrogenase	-
JYG36_RS20490 (JYG36_20490)	4484540..4486030	+	1491	WP_213602126.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (43-274)

Antitoxin

• Transcription regulator IclR, N-terminal (19-68)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 30626.92 Da
• Isoelectric Point: 6.8725

>T194968 WP_213602120.1 NZ_CP071007:4479545-4480414 [Pseudomonas sp. SORT22]
MLHATDHSLAGLAAQLQQRFPQRLVQLASGAQAIREAGHGPAIVLLHGIGSGAASWLQVALQLSQHARVIAWDAPGYGDS
SPLANPAPQAADYARRLRHLLDALQIDDCLLVGHSLGALSAAALAQQQPQRVRRLVLISPARGYGDPARAEQAQQVRNQR
LHNLEQLGIAQMANQRSAHMLSPAASSEARAWVQWNMARLLPQGYRQAIELLCGDDLLRYAALAVPCEVHCGAADSITLP
EDCQALAKALGAAFALIAEAGHASPIEQPEAVASLLARALEESLTGTAL

Nucleotide

• Length: 870 bp

>T194968 NZ_CP094240:c3079598-3078300 [Comamonas sp. 7D-2evo2]
ATGACGCATGAACTCGAAGTCTGGCTGTTTGAGCGGCGCGTGGGAAGCCTGTCGCTGGTGCATGGGCGGCTGAGCTTTGC
CTATGCGACCGAATGGTTGGCGCTGCCGCAGGCCACGGCTTTATCGCAGTCGCTGCCGCTGCAGGCTGAGCCCTTTGGCG
ATCACCAGACCCGGCCATTCTTTGCCGGTCTGCTGCCCGAGGGGCAGATGCGACGCCTGATTGCCCAGCAATTTCAGGTG
TCGGGCCAGAACGATTTTGCGTTGCTGGACCATATTGGAGGCGAATGCGCGGGGGCCGTGACCTTTCTGGAACCAGGGCA
AGCCTTGCCGCAGACTGACGGGGCTGGGGCGACCAGGGAATCGGGTGATGTGGAGTGGCTCAGCGATCAAAAGCTGCTCG
CCTTGCTGGACGAGCTGCCGCGCCGCCCCATGCTGGCGGGAGATGACGGGCTGCGGCTGTCGCTGGCCGGGGCGCAGGAC
AAGCTGCCCGTGGTGGTGGACGACAGCATTCCGGGCGCAGTGCGTATCGGTCTGCCGCGCAACGGCGCTCCCAGCTCGCA
TATCTTGAAGCCCGCCATCCATGCGGTGGAGGACAGCGTAGCCAACGAAGGCTTTTGCATGCTGCTGGCCCAGGTCATGG
GGCTGCGGCCTGCCAATGCCCGAATCCAGAGCGTGCTGGGCCGCTCGTTTTTGCTGGTGAAGCGCTATGACCGGGTGCTG
AAGGACGATGCGCAGGGCCAAGCGCAGCTGCAACGTCTGCACCAGGAAGACTTTTGCCAGGCGCTGGGCGTGGTGCCCGA
GCTGAAGTACCAGAACGAGGGCGGGCCAGGCCTGGCCCAATGCTTTGCCTTGGCGCGCAGCGTGACCCGCCCCAGCGCGC
CGCAGGTTCTGCGGCTGCTGGATGGGGTGATCTTCAATGCCCTGATCGGCAACCATGACGCACATGGCAAGAATTTCTCG
CTGCTTTATGGAGGAAGGGCGCCTGTGCTGGCACCGTTCTACGACCTGCTGGCTACGGCGATTTACCCCCAGCTGACGCC
CAAGATGGCAATGAAGATTGGCAGCAAATACAAGTTCAGCGAGCTGGAGGCCAGGCACTGGGAGCAGTTTGCGGAAGAAG
CAGGCCTTGCCAAGGCGGCGACGAGCAAGCGTTTGCAGCAGCTGGCGAACGAACTACCCGCTGCCGCGCGCAAGCTGCAG
GCCGCGCCACCGCATGGTTTTGCGGGCAATGCCGTGGTGACGCAGATCGTGCAGCTGATAGAGCAGCGCTGCGCCTTGAC
GCTGAGGCGCTTGGCCTGA

Antitoxin

Protein

• Length: 276 a.a.
• Molecular weight: 30416.81 Da
• Isoelectric Point: 6.3865

>AT194968 WP_045193445.1 NZ_CP071007:4480411-4481238 [Pseudomonas sp. SORT22]
MNDSDLLKDNQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSPCTPKTVLELFDLVQSDRQRGYVSGEGFFESSISTIAAPVRDHSGRVVAAMGVTIPTVQVAHINF
DGLLGHVRGSADELSRLLNYTPNAGSGRVTALMRD

Nucleotide

• Length: 828 bp

>AT194968 NZ_CP094240:c3079869-3079588 [Comamonas sp. 7D-2evo2]
ATGTCCACCATCCACACCACCGACCAACTGGGCACGGCCCTGCGCATCGCCCGCAAACAACTGGGGCTGACCCAGCCGCA
GCTTGCCTTGGCCGCAGGCGTGGGCACGCGGTTTATTGTAGATCTGGAGTCGGGCAAGCCCACGGTGCGGCTGGAGCATG
TGCTGCGGGTGATCGATGCGCTGGGGGGAGAGTTGCAGTTGGGCGGCTTGCCGGAAGCGGCGCATGAAGACGGGGCAGGC
CAGGCTGCCGCAGCAACGGAGGGCGCAGACCATGACGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A1H1EW67