194964

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2981702..2982230 Replicon chromosome
Accession NZ_CP070997
Organism Acinetobacter indicus strain LYS68A

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag JYB86_RS14080 Protein ID WP_000221358.1
Coordinates 2981702..2981995 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag JYB86_RS14085 Protein ID WP_000246756.1
Coordinates 2981985..2982230 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYB86_RS14045 2976956..2978281 + 1326 WP_127801714.1 ISNCY family transposase -
JYB86_RS14050 2978358..2978672 - 315 WP_205779192.1 BrnA antitoxin family protein -
JYB86_RS14055 2978659..2978946 - 288 WP_205779193.1 BrnT family toxin -
JYB86_RS14060 2979176..2979874 - 699 WP_205779194.1 hypothetical protein -
JYB86_RS14065 2979963..2980286 + 324 WP_205779195.1 hypothetical protein -
JYB86_RS14070 2980289..2981065 + 777 WP_205779196.1 hypothetical protein -
JYB86_RS14075 2981151..2981627 + 477 WP_205779197.1 hypothetical protein -
JYB86_RS14080 2981702..2981995 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JYB86_RS14085 2981985..2982230 - 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JYB86_RS14090 2982340..2983665 - 1326 WP_127801714.1 ISNCY family transposase -
JYB86_RS14095 2984017..2984151 - 135 Protein_2717 IS982 family transposase -
JYB86_RS14100 2984329..2984676 + 348 WP_205779198.1 hypothetical protein -
JYB86_RS14105 2984931..2985497 - 567 WP_000678311.1 recombinase family protein -
JYB86_RS14110 2985684..2986583 - 900 WP_177156119.1 cation diffusion facilitator family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2951166..2998945 47779
- inside IScluster/Tn - - 2965109..2983677 18568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T194964 WP_000221358.1 NZ_CP070997:c2981995-2981702 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T194964 NZ_CP094239:c5279720-5278842 [Comamonas sp. 7D-2evo1]
ATGCACGAGGATTTGCTGTCGCTGAAACTGCAGCTGCTGCAGACCGGTTTTCCCGAGCGGCTGGTGAAGCTTCCCCAGGG
CGCCCAGGTCGCCTGGCGTGAGGCAGGCGACGCCAGCTCCGACTTTGCGGTGGTGCTGCTGCATGGCATCAGCTCCGGGG
CTGCATCCTGGCTGGATGTGGCGCTGCAGCTGGCTGACAAAGTGCGTGTCCTGGCCTGGGATGCACCCGGTTATGGCGTG
TCGACGCCGCTGGCACAGTCGGCGCCTGCCGATGCCGACTATGCGCAGGCGCTGGCCCAGTCGCTGCTGGTGCTGGGCGT
GCGGCGCTGCATTCTGGTCGGGCACTCGCTGGGCGCCCTGATGGCAGCCAGGCTGGCTGCCATGGCCGCACCAGGACTGG
TCGAGCAACTGGTTCTCATCAGCCCGGCGGGCGGCTACGGCGCTGAGGCCAAGGCCGAGCAGCAGGCCAAGGTGCGCGAG
GGCCGGCTGGCGGCTCTGGCAGAGAAGGGCGTCGCCGGTCTGGCGGCCGTCATCGACCAGCGTCTGGTGTCCTCCGAGGC
TCCTGAAGTCGTGCGTGCATGGGTGCGCTGGAATACGGCGCGCATGCAGCCGCAGGGCTATGCGCAGGCGGTCGAGCTGC
TTTGCGGCAGCGATCTGGCACAGGCACGGGGCAGGCTTGACATGCCGGTCGAGGTTTGGGTCGGCGAGCACGATGTGGTG
ACTACACCTGCAGCTTGCAAGTCCTGGTCCGAAATGCTGGGCGCGCACTACGGTACGCTTGCGGCTGCCGGTCATGCTTC
ACCCGTGGAACAACCAATGGAGGTCGCGCATAGGCTGGCATCTTTGTTGAACCAAAGCTATTGCCCCAATACCAGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT194964 WP_000246756.1 NZ_CP070997:c2982230-2981985 [Acinetobacter indicus]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT194964 NZ_CP094239:c5278836-5278030 [Comamonas sp. 7D-2evo1]
ATGAGCGAAACCTCCGAGATTTCAACCAACGAACAAGACCGTTACACCGTACCAGCTCTGGACCGAGGACTGCGCCTGCT
GGCCTGCTTTGGCCCGGCGCAACCGGTCTGGAGCGCGCCCGAGCTGGCGCGCAGCCTCGAGCTGCCGCGCTCCACGGTGT
TTCGCATGTTGACCACGCTTGAAAACTCGGGGTATCTGCAGCGCAGCGGCACCGAATACCGGCTCGGTCTGGCCGTGCTG
CGCCTGGGCTATGACTACCTGTCCACCCAGCCGCTGGCGCAACTGGCCGAGCCTGTGCTGCAGGCCTTGTGCGATGAGCT
GGGCATGACCAGCAATCTTGCATTGCGCGACGGCACTTCCGTGGTCTATGTGGCACGCGTCACTCCGTCCGGAGCATTCC
AGGGCGCTGTGCGCGTGGGTTCGCGTCTGCCGGCGCATGCGACGGTGCTGGGACGAGCCCTGTTGCATGACATGGACGGC
GCGCAGCTGCGCTCGGTGTTTGGCGGCGAGGAACTGCCCCAGTTCTCCGAGAGCACGCCGCGCAATGTCGACGAGCTGCT
GCGCCTGCTGGCCGAGGATCGCGAGCGTGGTTATGCCATGGGCGAGGGCTTTTACGAGCCTGGCGTTTCCAGTATTGCAG
CGCCGGTGCGCGCCGCAGACGGGCAGGTGGTTGCGGGGCTGGCCATGGCCATTCCGTTTACCGAGCTGGGGCCCGAAAAA
ACCCAGCTCTGGGTGCAGAAGGTGCAGCAGGCGGCAGAGACTCTGTCCGCCCATTTGCGCCAGCAGCACCCGGACCATTT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References