Detailed information of TA system TA194963

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 2978358..2978946
• Replicon: chromosome
• Accession: NZ_CP070997
• Organism: Acinetobacter indicus strain LYS68A

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: JYB86_RS14055
• Protein ID: WP_205779193.1
• Coordinates: 2978659..2978946 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: JYB86_RS14050
• Protein ID: WP_205779192.1
• Coordinates: 2978358..2978672 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYB86_RS14035	2974122..2974460	-	339	WP_004897649.1	hypothetical protein	-
JYB86_RS14040	2974447..2976258	-	1812	WP_004733211.1	copper resistance system multicopper oxidase	-
JYB86_RS14045	2976956..2978281	+	1326	WP_127801714.1	ISNCY family transposase	-
JYB86_RS14050	2978358..2978672	-	315	WP_205779192.1	BrnA antitoxin family protein	Antitoxin
JYB86_RS14055	2978659..2978946	-	288	WP_205779193.1	BrnT family toxin	Toxin
JYB86_RS14060	2979176..2979874	-	699	WP_205779194.1	hypothetical protein	-
JYB86_RS14065	2979963..2980286	+	324	WP_205779195.1	hypothetical protein	-
JYB86_RS14070	2980289..2981065	+	777	WP_205779196.1	hypothetical protein	-
JYB86_RS14075	2981151..2981627	+	477	WP_205779197.1	hypothetical protein	-
JYB86_RS14080	2981702..2981995	-	294	WP_000221358.1	type II toxin-antitoxin system RelE/ParE family toxin	-
JYB86_RS14085	2981985..2982230	-	246	WP_000246756.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
JYB86_RS14090	2982340..2983665	-	1326	WP_127801714.1	ISNCY family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2951166..2998945	47779
	-	inside	IScluster/Tn	-	-	2965109..2983677	18568

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (41-96)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11290.72 Da
• Isoelectric Point: 5.6205

>T194963 WP_205779193.1 NZ_CP070997:c2978946-2978659 [Acinetobacter indicus]
MEQYFEWDEAKNRKNQKKHDISFETASLIFEDPLRISIQDRHTNGEERWQTIGKVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERDKYEHG

Nucleotide

• Length: 288 bp

>T194963 NZ_CP094239:3931873-3932049 [Comamonas sp. 7D-2evo1]
GTGAAAATCAGCGAATTCAAGCGGTGGCTTGAAGCGCAGGGGGTCAAAGTCGAGAACGGTACGAATCACTGGAGGCTGTA
CCACAACGGCAACACAAGCACCCTGCCAAGGCACCCAAGTAAAGAGCTGAAGGAAGGCACAAGACGCGCAATCCTGAAGC
AACTAGGAATCAACTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12284.95 Da
• Isoelectric Point: 8.4842

>AT194963 WP_205779192.1 NZ_CP070997:c2978672-2978358 [Acinetobacter indicus]
MSMVRHSRKELNEKFSDKQDAEIQRLLAKGTVPDDQLDLSDMPEITEWSNAVRYNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Nucleotide

• Length: 315 bp

>AT194963 NZ_CP094239:3932115-3932543 [Comamonas sp. 7D-2evo1]
ATGCAAAAGTATCCTGCCCGCTTCGATCCCGCCGACGAAGGGGGCTACACCGTCACGTTTCGGGATATTCCCGAAGCAAT
CACCCAGGGCGATGACCTGGCAGAGGCTGAATCTATGGCGCGTGACGCACTGGTCACGGCCATGGAGTTCTATTTCGAGG
CAGGCCGCGCCGTGCCCGCGCCCAGCAAGGCAGAAAAGGGCGAGCGCCTGGTGGAGCTGCCCGCCAGTGTCGCCGTCAAG
GTGGCGCTGCTGAATGCCCGTCTTGCCACAGGTGCCAGGCCCGCCGACGTGGCCCGCGCCATGGGCGTGAAACCCCAAGA
AATGACCCGCGTTTTTGACCTGGGCCATGCCACCAAGATCGACACCGTTGCGGCCGCGCTGGCTGCCATGGGCTACGAGC
TGGAATTGACCGTGCGCCCGATCAAGTAA