Detailed information of TA system TA194962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): NpoTA/ParE(toxin)
• Location: 1720317..1721432
• Replicon: chromosome
• Accession: NZ_CP070997
• Organism: Acinetobacter indicus strain LYS68A

Toxin (Protein)

• Gene name: NpoT
• Uniprot ID: V2U6R6
• Locus tag: JYB86_RS08080
• Protein ID: WP_016658124.1
• Coordinates: 1721268..1721432 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: NpoA
• Uniprot ID: -
• Locus tag: JYB86_RS08075
• Protein ID: WP_045794748.1
• Coordinates: 1720317..1721186 (+)
• Length: 290 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYB86_RS08050	1715522..1716331	-	810	WP_005178046.1	formate/nitrite transporter family protein	-
JYB86_RS08055	1716624..1717074	+	451	Protein_1555	cyanase	-
JYB86_RS08060	1717263..1717634	-	372	WP_205778836.1	hypothetical protein	-
JYB86_RS08065	1718074..1719315	-	1242	WP_205778837.1	MFS transporter	-
JYB86_RS08070	1719974..1720213	+	240	WP_104471337.1	DUF2171 domain-containing protein	-
JYB86_RS08075	1720317..1721186	+	870	WP_045794748.1	SDR family oxidoreductase	Antitoxin
JYB86_RS08080	1721268..1721432	+	165	WP_016658124.1	hypothetical protein	Toxin
JYB86_RS08085	1721532..1722950	-	1419	WP_205778838.1	iron-containing redox enzyme family protein	-
JYB86_RS08090	1723252..1724409	-	1158	WP_171065080.1	acyl-CoA desaturase	-
JYB86_RS08095	1724433..1725455	-	1023	WP_160243166.1	ferredoxin reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6182.76 Da
• Isoelectric Point: 10.1466

>T194962 WP_016658124.1 NZ_CP070997:1721268-1721432 [Acinetobacter indicus]
MSRGDKSAYTDKQKRQARHIIESEKERGHSEEEAERIGWSTVNKQDGGGKKKSH

Nucleotide

• Length: 165 bp

>T194962 NZ_CP094239:3770052-3770228 [Comamonas sp. 7D-2evo1]
ATGAAGCAAAGCGAGTTCCAGAGATGGCTCGCTGCGCAGGGAGCAACTTTCAGCCACGGCACACGCCACTTGAAGGTTTT
CCTGAACGGCAAGCAAACAATAATGCCCCGGCACCCAAGCCAAGAGATTGGCGAAGGACTCAGAAAAGCGATTCTGAAAC
AGCTAGGACTTAAATAG

Antitoxin

Protein

• Length: 290 a.a.
• Molecular weight: 31852.95 Da
• Isoelectric Point: 4.7467

>AT194962 WP_045794748.1 NZ_CP070997:1720317-1721186 [Acinetobacter indicus]
MNHYPDSPSPQEKQEHQPGVQYKMTPEPEIIKSNYQGSQKLKDKVALITGGDSGIGRSVAVLFAREGANIIIPYLEEDQD
AQDTKRLVEQEGCQCLLIQCDLRQHAAVQQMVDLALQQFPHINILVNNAAVQYPQKTIEDINPEQLHKTFETNLYPLFYV
TQLLIPQMQPGDSIINTTSITSYQGHNELIDYASTKGAITAFTRSLSTNLLKNKTGIRVNGVAPGPIWTPLIPSSFDEEQ
LKGFGEDTPMGRMGQPSEVAPAYLFLASDEASYISGQVIHVNGGTIVNG

Nucleotide

• Length: 870 bp

>AT194962 NZ_CP094239:3770293-3770730 [Comamonas sp. 7D-2evo1]
ATGCGATTTCCTGCAAACATCGAGCCCGATGGTGATGGCTTCATGGTCTCGTTTCCCGATATCCCGGAGGCATTGACCTG
CGGCGATACCTACGATGAGGCCGTATCCATGGCCCATGATGCGCTACTGACTGCGATGGACTTCTATTTTGACGATCGCC
GCGCCGTCCCTGAGCCATCCAAGGCCGCCAAGGGCCAGGTGCTTATCTCTTTGCCGGCCAGCGTGTCGGCAAAGGTGCTG
CTGCTCAACGAGATGGTGCATCAAGGCGTGCGCCCCATCGACCTGGCAGCACGCATGGGCACGACTAAACAAGAAGTCAA
CCGGCTGACGGACCTCAAGCATGCAACCAAGATCGACACCATCGCCAAAGCCCTGGCGACCATGGGCCTTGATCTGGAGC
TAGGCGTGCGCCGCTCAGCTACTGCAGCCGCTCGATAA

Structures

Toxin

• AlphaFold DB: V2U6R6