Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 87933..88813 Replicon chromosome
Accession NZ_CP070995
Organism Bifidobacterium longum subsp. longum strain KCTC 3128

Toxin (Protein)


Gene name relE Uniprot ID F8APN2
Locus tag BLL128_RS00380 Protein ID WP_007052625.1
Coordinates 87933..88424 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4R0V8T5
Locus tag BLL128_RS00385 Protein ID WP_013410773.1
Coordinates 88421..88813 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLL128_RS00360 83015..84247 + 1233 WP_007056207.1 sensor histidine kinase -
BLL128_RS00365 84282..85007 + 726 WP_007056206.1 response regulator transcription factor -
BLL128_RS00370 85047..85688 + 642 WP_007052627.1 GNAT family N-acetyltransferase -
BLL128_RS00375 85778..87883 + 2106 WP_013582801.1 DUF262 domain-containing protein -
BLL128_RS00380 87933..88424 - 492 WP_007052625.1 type II toxin-antitoxin system VapC family toxin Toxin
BLL128_RS00385 88421..88813 - 393 WP_013410773.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BLL128_RS00390 88958..91657 - 2700 WP_013582802.1 aconitate hydratase AcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 10058..187411 177353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-146)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18531.70 Da        Isoelectric Point: 6.2348

>T194958 WP_007052625.1 NZ_CP070995:c88424-87933 [Bifidobacterium longum subsp. longum]
MRQSKQVSILCDTNILIYYMLCTPRFIKDVMKLFERCVEREVKLSCASLSLKDVFYITPERFKERFMNDESMVVATTAKL
ILPEVAWSGISKLKELMTIVPIGAEECELAQSLRHAHNDFEDDLIIAAAQQSGATYVVTYDKKLAKHFPEYCKTPAEIVA
ALA

Download         Length: 492 bp

>T194958 NZ_CP094239:2237771-2238067 [Comamonas sp. 7D-2evo1]
ATGTTCACCATCAAGCGAACCGCTGAATTTGATGCATGGCTATTCGGCCTGCGCGACACCATGACGCGCATCCGCCTTGC
CAAGCGACTGGACAAGGTGCAGCGTGGCCCGCTTGGAGATACAAAGCCCGTGGGTGATGGCGTGCATGAGCTGCGCGAGG
ACTTCGGCCCTGGCTGGTGCATGTACTACGTGCAGCACGGTGATGTGCTGGTGGTGATGCTGGGCGGAGGGGACAAGTCC
ACCCAGCAGGCCGACATTCAGGCCGCGATTGCTTTGTCCAAGACCCTGGAGGACTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15205.33 Da        Isoelectric Point: 5.4043

>AT194958 WP_013410773.1 NZ_CP070995:c88813-88421 [Bifidobacterium longum subsp. longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDEIADERLKEYRHQSDYARYLEKERSLS

Download         Length: 393 bp

>AT194958 NZ_CP094239:2238070-2238366 [Comamonas sp. 7D-2evo1]
ATGACCAAGATTGCAGACCTGCCCACCTTTGATATGGCAGAGCACCTGAAAACCGATGAAGACCTGGCTGCCTACCTATC
CTTGGTGCTGGAAGAAGACGACCCCGCAGAGCTGGCCAACGCTCTGGGTGTGATTGCCCGCGCCCGTGGCATGACCGAGA
TTGCCAGCGCCAGCGGCCTGACCCGCGAGGCTCTTTACAAGGCGCTACGCCCTGGCAGCCAGCCGCGCTTTGACACCATC
CGCCGGGTCTGTGGTGCCCTTGGGGTTCGCTTGGTGGCCCAGCCTATCCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8APN2

Antitoxin

Source ID Structure
AlphaFold DB A0A4R0V8T5

References