Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 258638..259250 Replicon chromosome
Accession NZ_CP070994
Organism Streptococcus pyogenes strain M11318

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag JYQ80_RS01370 Protein ID WP_010922665.1
Coordinates 258638..258973 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag JYQ80_RS01375 Protein ID WP_002988079.1
Coordinates 258963..259250 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYQ80_RS01330 254016..254534 + 519 WP_002982682.1 NYN domain-containing protein -
JYQ80_RS01335 254631..255491 + 861 WP_002982687.1 DegV family protein -
JYQ80_RS01340 255627..256133 + 507 WP_002988070.1 hypothetical protein -
JYQ80_RS01345 256130..256336 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
JYQ80_RS01350 256554..257000 + 447 WP_002982710.1 50S ribosomal protein L13 -
JYQ80_RS01355 257021..257413 + 393 WP_002982716.1 30S ribosomal protein S9 -
JYQ80_RS01360 257533..257970 - 438 WP_076639988.1 site-specific integrase -
JYQ80_RS01365 258016..258486 - 471 Protein_232 integrase -
JYQ80_RS01370 258638..258973 - 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JYQ80_RS01375 258963..259250 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
JYQ80_RS01380 259911..260684 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
JYQ80_RS01385 261131..261559 + 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
JYQ80_RS01390 261594..262109 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
JYQ80_RS01395 262157..263086 + 930 WP_010922663.1 tagatose-6-phosphate kinase -
JYQ80_RS01400 263090..264073 + 984 WP_002982755.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T194957 WP_010922665.1 NZ_CP070994:c258973-258638 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T194957 NZ_CP094238:c5234717-5233839 [Comamonas sp. 7D-2]
ATGCACGAGGATTTGCTGTCGCTGAAACTGCAGCTGCTGCAGACCGGTTTTCCCGAGCGGCTGGTGAAGCTTCCCCAGGG
CGCCCAGGTCGCCTGGCGTGAGGCAGGCGACGCCAGCTCCGACTTTGCGGTGGTGCTGCTGCATGGCATCAGCTCCGGGG
CTGCATCCTGGCTGGATGTGGCGCTGCAGCTGGCTGACAAAGTGCGTGTCCTGGCCTGGGATGCACCCGGTTATGGCGTG
TCGACGCCGCTGGCACAGTCGGCGCCTGCCGATGCCGACTATGCGCAGGCGCTGGCCCAGTCGCTGCTGGTGCTGGGCGT
GCGGCGCTGCATTCTGGTCGGGCACTCGCTGGGCGCCCTGATGGCAGCCAGGCTGGCTGCCATGGCCGCACCAGGACTGG
TCGAGCAACTGGTTCTCATCAGCCCGGCGGGCGGCTACGGCGCTGAGGCCAAGGCCGAGCAGCAGGCCAAGGTGCGCGAG
GGCCGGCTGGCGGCTCTGGCAGAGAAGGGCGTCGCCGGTCTGGCGGCCGTCATCGACCAGCGTCTGGTGTCCTCCGAGGC
TCCTGAAGTCGTGCGTGCATGGGTGCGCTGGAATACGGCGCGCATGCAGCCGCAGGGCTATGCGCAGGCGGTCGAGCTGC
TTTGCGGCAGCGATCTGGCACAGGCACGGGGCAGGCTTGACATGCCGGTCGAGGTTTGGGTCGGCGAGCACGATGTGGTG
ACTACACCTGCAGCTTGCAAGTCCTGGTCCGAAATGCTGGGCGCGCACTACGGTACGCTTGCGGCTGCCGGTCATGCTTC
ACCCGTGGAACAACCAATGGAGGTCGCGCATAGGCTGGCATCTTTGTTGAACCAAAGCTATTGCCCCAATACCAGCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT194957 WP_002988079.1 NZ_CP070994:c259250-258963 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT194957 NZ_CP094238:c5233833-5233027 [Comamonas sp. 7D-2]
ATGAGCGAAACCTCCGAGATTTCAACCAACGAACAAGACCGTTACACCGTACCAGCTCTGGACCGAGGACTGCGCCTGCT
GGCCTGCTTTGGCCCGGCGCAACCGGTCTGGAGCGCGCCCGAGCTGGCGCGCAGCCTCGAGCTGCCGCGCTCCACGGTGT
TTCGCATGTTGACCACGCTTGAAAACTCGGGGTATCTGCAGCGCAGCGGCACCGAATACCGGCTCGGTCTGGCCGTGCTG
CGCCTGGGCTATGACTACCTGTCCACCCAGCCGCTGGCGCAACTGGCCGAGCCTGTGCTGCAGGCCTTGTGCGATGAGCT
GGGCATGACCAGCAATCTTGCATTGCGCGACGGCACTTCCGTGGTCTATGTGGCACGCGTCACTCCGTCCGGAGCATTCC
AGGGCGCTGTGCGCGTGGGTTCGCGTCTGCCGGCGCATGCGACGGTGCTGGGACGAGCCCTGTTGCATGACATGGACGGC
GCGCAGCTGCGCTCGGTGTTTGGCGGCGAGGAACTGCCCCAGTTCTCCGAGAGCACGCCGCGCAATGTCGACGAGCTGCT
GCGCCTGCTGGCCGAGGATCGCGAGCGTGGTTATGCCATGGGCGAGGGCTTTTACGAGCCTGGCGTTTCCAGTATTGCAG
CGCCGGTGCGCGCCGCAGACGGGCAGGTGGTTGCGGGGCTGGCCATGGCCATTCCGTTTACCGAGCTGGGGCCCGAAAAA
ACCCAGCTCTGGGTGCAGAAGGTGCAGCAGGCGGCAGAGACTCTGTCCGCCCATTTGCGCCAGCAGCACCCGGACCATTT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References