Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2668922..2669436 Replicon chromosome
Accession NZ_CP070991
Organism Staphylococcus aureus strain CBS2016-05

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JYA46_RS13295 Protein ID WP_000581792.1
Coordinates 2669227..2669436 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag JYA46_RS13290 Protein ID WP_000138934.1
Coordinates 2668922..2669215 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA46_RS13270 (2664261) 2664261..2664902 + 642 WP_000483160.1 thiamine phosphate synthase -
JYA46_RS13275 (2664988) 2664988..2665860 + 873 WP_072491794.1 membrane protein insertase YidC -
JYA46_RS13280 (2666597) 2666597..2667244 - 648 WP_065315756.1 HD domain-containing protein -
JYA46_RS13285 (2667272) 2667272..2668756 - 1485 WP_098818134.1 cardiolipin synthase -
JYA46_RS13290 (2668922) 2668922..2669215 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
JYA46_RS13295 (2669227) 2669227..2669436 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JYA46_RS13300 (2669564) 2669564..2669701 + 138 WP_000828354.1 Lmo0850 family protein -
JYA46_RS13305 (2669965) 2669965..2671167 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
JYA46_RS13310 (2671485) 2671485..2672555 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JYA46_RS13315 (2672570) 2672570..2673928 + 1359 WP_072491791.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T194955 WP_000581792.1 NZ_CP070991:2669227-2669436 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T194955 NZ_CP094238:c3480028-3479732 [Comamonas sp. 7D-2]
ATGACCAAGATTGCAGACCTGCCCACCTTTGATATGGCAGAGCACCTGAAAACCGATGAAGACCTGGCTGCCTACCTATC
CTTGGTGCTGGAAGAAGACGACCCCGCAGAGCTGGCCAACGCTCTGGGTGTGATTGCCCGCGCCCGTGGCATGACCGAGA
TTGCCAGCGCCAGCGGCCTGACCCGCGAGGCTCTTTACAAGGCGCTACGCCCTGGCAGCCAGCCGCGCTTTGACACCATC
CGCCGGGTCTGTGGTGCCCTTGGGGTTCGCTTGGTGGCCCAGCCTATCCACGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT194955 WP_000138934.1 NZ_CP070991:2668922-2669215 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT194955 NZ_CP094238:c3480327-3480031 [Comamonas sp. 7D-2]
ATGTTCACCATCAAGCGAACCGCTGAATTTGATGCATGGCTATTCGGCCTGCGCGACACCATGACGCGCATCCGCCTTGC
CAAGCGACTGGACAAGGTGCAGCGTGGCCCGCTTGGAGATACAAAGCCCGTGGGTGATGGCGTGCATGAGCTGCGCGAGG
ACTTCGGCCCTGGCTGGTGCATGTACTACGTGCAGCACGGTGATGTGCTGGTGGTGATGCTGGGCGGAGGGGACAAGTCC
ACCCAGCAGGCCGACATTCAGGCCGCGATTGCTTTGTCCAAGACCCTGGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References