Detailed information of TA system TA194955

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2668922..2669436
• Replicon: chromosome
• Accession: NZ_CP070991
• Organism: Staphylococcus aureus strain CBS2016-05

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: T1YA99
• Locus tag: JYA46_RS13295
• Protein ID: WP_000581792.1
• Coordinates: 2669227..2669436 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A0D1GBN9
• Locus tag: JYA46_RS13290
• Protein ID: WP_000138934.1
• Coordinates: 2668922..2669215 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7843.77 Da
• Isoelectric Point: 4.1008

>T194955 WP_000581792.1 NZ_CP070991:2669227-2669436 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T194955 NZ_CP094238:c3480028-3479732 [Comamonas sp. 7D-2]
ATGACCAAGATTGCAGACCTGCCCACCTTTGATATGGCAGAGCACCTGAAAACCGATGAAGACCTGGCTGCCTACCTATC
CTTGGTGCTGGAAGAAGACGACCCCGCAGAGCTGGCCAACGCTCTGGGTGTGATTGCCCGCGCCCGTGGCATGACCGAGA
TTGCCAGCGCCAGCGGCCTGACCCGCGAGGCTCTTTACAAGGCGCTACGCCCTGGCAGCCAGCCGCGCTTTGACACCATC
CGCCGGGTCTGTGGTGCCCTTGGGGTTCGCTTGGTGGCCCAGCCTATCCACGCCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11185.77 Da
• Isoelectric Point: 6.2243

>AT194955 WP_000138934.1 NZ_CP070991:2668922-2669215 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT194955 NZ_CP094238:c3480327-3480031 [Comamonas sp. 7D-2]
ATGTTCACCATCAAGCGAACCGCTGAATTTGATGCATGGCTATTCGGCCTGCGCGACACCATGACGCGCATCCGCCTTGC
CAAGCGACTGGACAAGGTGCAGCGTGGCCCGCTTGGAGATACAAAGCCCGTGGGTGATGGCGTGCATGAGCTGCGCGAGG
ACTTCGGCCCTGGCTGGTGCATGTACTACGTGCAGCACGGTGATGTGCTGGTGGTGATGCTGGGCGGAGGGGACAAGTCC
ACCCAGCAGGCCGACATTCAGGCCGCGATTGCTTTGTCCAAGACCCTGGAGGACTGA

Structures

Toxin

• PDB: 6FF1

Antitoxin

• AlphaFold DB: A0A0D1GBN9