Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 172866..173642 Replicon chromosome
Accession NZ_CP070991
Organism Staphylococcus aureus strain CBS2016-05

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag JYA46_RS01165 Protein ID WP_098817916.1
Coordinates 173490..173642 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag JYA46_RS01160 Protein ID WP_001251217.1
Coordinates 172866..173465 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA46_RS01140 (168782) 168782..170239 + 1458 WP_000649900.1 ABC transporter permease subunit -
JYA46_RS01145 (170232) 170232..170954 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
JYA46_RS01150 (171105) 171105..172232 + 1128 WP_172440429.1 tRNA epoxyqueuosine(34) reductase QueG -
JYA46_RS01155 (172237) 172237..172707 + 471 WP_098817917.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
JYA46_RS01160 (172866) 172866..173465 + 600 WP_001251217.1 hypothetical protein Antitoxin
JYA46_RS01165 (173490) 173490..173642 + 153 WP_098817916.1 SAS053 family protein Toxin
JYA46_RS01170 (174306) 174306..174701 + 396 WP_000901023.1 hypothetical protein -
JYA46_RS01175 (174897) 174897..176282 + 1386 WP_072491880.1 class II fumarate hydratase -
JYA46_RS01180 (176732) 176732..177553 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5864.22 Da        Isoelectric Point: 3.9367

>T194946 WP_098817916.1 NZ_CP070991:173490-173642 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMGQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T194946 NZ_CP094237:4136146-4136364 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22391.52 Da        Isoelectric Point: 5.1445

>AT194946 WP_001251217.1 NZ_CP070991:172866-173465 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIEFIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT194946 NZ_CP094237:4135745-4136119 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References