Detailed information of TA system TA194946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 172866..173642
• Replicon: chromosome
• Accession: NZ_CP070991
• Organism: Staphylococcus aureus strain CBS2016-05

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: JYA46_RS01165
• Protein ID: WP_098817916.1
• Coordinates: 173490..173642 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: JYA46_RS01160
• Protein ID: WP_001251217.1
• Coordinates: 172866..173465 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA46_RS01140 (168782)	168782..170239	+	1458	WP_000649900.1	ABC transporter permease subunit	-
JYA46_RS01145 (170232)	170232..170954	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
JYA46_RS01150 (171105)	171105..172232	+	1128	WP_172440429.1	tRNA epoxyqueuosine(34) reductase QueG	-
JYA46_RS01155 (172237)	172237..172707	+	471	WP_098817917.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
JYA46_RS01160 (172866)	172866..173465	+	600	WP_001251217.1	hypothetical protein	Antitoxin
JYA46_RS01165 (173490)	173490..173642	+	153	WP_098817916.1	SAS053 family protein	Toxin
JYA46_RS01170 (174306)	174306..174701	+	396	WP_000901023.1	hypothetical protein	-
JYA46_RS01175 (174897)	174897..176282	+	1386	WP_072491880.1	class II fumarate hydratase	-
JYA46_RS01180 (176732)	176732..177553	-	822	WP_000669380.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5864.22 Da
• Isoelectric Point: 3.9367

>T194946 WP_098817916.1 NZ_CP070991:173490-173642 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMGQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T194946 NZ_CP094237:4136146-4136364 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22391.52 Da
• Isoelectric Point: 5.1445

>AT194946 WP_001251217.1 NZ_CP070991:172866-173465 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIEFIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT194946 NZ_CP094237:4135745-4136119 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG