194926

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 872936..873413 Replicon chromosome
Accession NZ_CP070986
Organism Staphylococcus aureus strain WBG8287

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JYH18_RS04105 Protein ID WP_000052076.1
Coordinates 872936..873124 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JYH18_RS04110 Protein ID WP_001059690.1
Coordinates 873153..873413 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYH18_RS04075 868926..869447 + 522 WP_000824464.1 hypothetical protein -
JYH18_RS04080 869788..870474 + 687 WP_001793574.1 thermonuclease family protein -
JYH18_RS04085 870831..871031 + 201 WP_001059082.1 cold-shock protein -
JYH18_RS04090 871527..871745 - 219 WP_000005886.1 hypothetical protein -
JYH18_RS04095 871807..872091 - 285 WP_001004401.1 hypothetical protein -
JYH18_RS04100 872179..872748 - 570 WP_001106654.1 hypothetical protein -
JYH18_RS04105 872936..873124 - 189 WP_000052076.1 hypothetical protein Toxin
JYH18_RS04110 873153..873413 - 261 WP_001059690.1 hypothetical protein Antitoxin
JYH18_RS04115 873753..873956 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JYH18_RS04120 873953..874189 - 237 WP_000368687.1 hypothetical protein -
JYH18_RS04125 874413..874994 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
JYH18_RS04130 875043..875660 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
JYH18_RS04135 875815..876309 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JYH18_RS04140 876708..877130 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
JYH18_RS04145 877278..877994 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T194926 WP_000052076.1 NZ_CP070986:c873124-872936 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T194926 NZ_CP094228:57636-58079 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT194926 WP_001059690.1 NZ_CP070986:c873413-873153 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT194926 NZ_CP094228:57409-57639 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References