Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2111492..2112006 Replicon chromosome
Accession NZ_CP070983
Organism Staphylococcus aureus strain WBG8366

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JX573_RS10455 Protein ID WP_000581792.1
Coordinates 2111492..2111701 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JX573_RS10460 Protein ID WP_000138932.1
Coordinates 2111713..2112006 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JX573_RS10435 2107000..2108358 - 1359 WP_000611459.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JX573_RS10440 2108373..2109443 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JX573_RS10445 2109761..2110963 + 1203 WP_001109936.1 rod shape-determining protein RodA -
JX573_RS10450 2111227..2111364 - 138 WP_000828354.1 hypothetical protein -
JX573_RS10455 2111492..2111701 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
JX573_RS10460 2111713..2112006 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JX573_RS10465 2112172..2113656 + 1485 WP_000571549.1 cardiolipin synthase -
JX573_RS10470 2113684..2114331 + 648 WP_001187630.1 HD domain-containing protein -
JX573_RS10475 2114797..2115669 - 873 WP_000725802.1 membrane protein insertase YidC -
JX573_RS10480 2115755..2116396 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T194920 WP_000581792.1 NZ_CP070983:c2111701-2111492 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T194920 NZ_CP094227:c4665228-4664845 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT194920 WP_000138932.1 NZ_CP070983:c2112006-2111713 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT194920 NZ_CP094227:c4665470-4665228 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References