Detailed information of TA system TA194912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 819053..819582
• Replicon: chromosome
• Accession: NZ_CP070983
• Organism: Staphylococcus aureus strain WBG8366

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: JX573_RS03895
• Protein ID: WP_001103939.1
• Coordinates: 819265..819582 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: JX573_RS03890
• Protein ID: WP_001058494.1
• Coordinates: 819053..819262 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JX573_RS03855	815383..815847	+	465	WP_001085185.1	SsrA-binding protein SmpB	-
JX573_RS03865	816410..817516	-	1107	WP_000149511.1	site-specific integrase	-
JX573_RS03870	817506..818309	-	804	WP_000358990.1	helix-turn-helix domain-containing protein	-
JX573_RS03875	818445..818648	+	204	WP_001045296.1	transcriptional regulator	-
JX573_RS03880	818684..818902	+	219	WP_000163544.1	helix-turn-helix domain-containing protein	-
JX573_RS03885	818914..819060	+	147	WP_000784885.1	hypothetical protein	-
JX573_RS03890	819053..819262	+	210	WP_001058494.1	hypothetical protein	Antitoxin
JX573_RS03895	819265..819582	+	318	WP_001103939.1	DUF1474 family protein	Toxin
JX573_RS03900	819646..820515	+	870	WP_001002717.1	primase alpha helix C-terminal domain-containing protein	-
JX573_RS03905	820532..821989	+	1458	WP_000390453.1	virulence-associated E family protein	-
JX573_RS03910	822290..822652	+	363	WP_001039170.1	hypothetical protein	-
JX573_RS03915	822654..822938	+	285	WP_000998185.1	hypothetical protein	-
JX573_RS03920	822935..823576	+	642	WP_001019808.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sec / sell / vWbp	816410..868377	51967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T194912 WP_001103939.1 NZ_CP070983:819265-819582 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T194912 NZ_CP094227:356072-356389 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT194912 WP_001058494.1 NZ_CP070983:819053-819262 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT194912 NZ_CP094227:356382-356669 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IY59