Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5625468..5626084 Replicon chromosome
Accession NZ_CP070982
Organism Pseudomonas entomophila strain Small

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JYG34_RS24665 Protein ID WP_213658749.1
Coordinates 5625893..5626084 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JYG34_RS24660 Protein ID WP_213658748.1
Coordinates 5625468..5625875 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG34_RS24630 (JYG34_24630) 5620974..5621120 - 147 WP_177323902.1 hypothetical protein -
JYG34_RS24635 (JYG34_24635) 5621515..5622426 + 912 WP_213658744.1 WYL domain-containing protein -
JYG34_RS24640 (JYG34_24640) 5622725..5622940 - 216 WP_044488541.1 hypothetical protein -
JYG34_RS24645 (JYG34_24645) 5623145..5624287 + 1143 WP_213658745.1 copper-containing nitrite reductase -
JYG34_RS24650 (JYG34_24650) 5624366..5624584 + 219 WP_213658746.1 DUF3079 domain-containing protein -
JYG34_RS24655 (JYG34_24655) 5624627..5625448 + 822 WP_213658747.1 suppressor of fused domain protein -
JYG34_RS24660 (JYG34_24660) 5625468..5625875 - 408 WP_213658748.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JYG34_RS24665 (JYG34_24665) 5625893..5626084 - 192 WP_213658749.1 type II toxin-antitoxin system HicA family toxin Toxin
JYG34_RS24670 (JYG34_24670) 5626348..5627217 - 870 WP_213658750.1 LysR family transcriptional regulator -
JYG34_RS24675 (JYG34_24675) 5627230..5629476 - 2247 WP_213658751.1 heavy metal translocating P-type ATPase -
JYG34_RS24680 (JYG34_24680) 5629605..5630048 + 444 WP_011536217.1 cadmium resistance transcriptional regulator CadR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7100.20 Da        Isoelectric Point: 11.0014

>T194911 WP_213658749.1 NZ_CP070982:c5626084-5625893 [Pseudomonas entomophila]
MNSREMISVIEADGWYRVRSKGSHHHFKHPHKTGLVTIPHPKKDLLPATAASILRQARIGYAS

Download         Length: 192 bp

>T194911 NZ_CP094227:c231906-231688 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14675.69 Da        Isoelectric Point: 4.6025

>AT194911 WP_213658748.1 NZ_CP070982:c5625875-5625468 [Pseudomonas entomophila]
MLFPIAILPGDDQHAWGVEVPDIPGCFSAGDDLDDAIAMAREAIEGHLELLAQDQQEIPKAGKVSEHAANPAYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALKVLQGK

Download         Length: 408 bp

>AT194911 NZ_CP094227:c232307-231933 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References