Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 744318..744964 Replicon chromosome
Accession NZ_CP070982
Organism Pseudomonas entomophila strain Small

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JYG34_RS03305 Protein ID WP_213659467.1
Coordinates 744318..744500 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JYG34_RS03310 Protein ID WP_213659468.1
Coordinates 744557..744964 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG34_RS03280 (JYG34_03280) 739338..739961 - 624 WP_213659462.1 lysophospholipid acyltransferase family protein -
JYG34_RS03285 (JYG34_03285) 739972..740391 - 420 WP_213659463.1 hypothetical protein -
JYG34_RS03290 (JYG34_03290) 740388..741713 - 1326 WP_213659464.1 phosphatase PAP2/dual specificity phosphatase family protein -
JYG34_RS03295 (JYG34_03295) 741713..743467 - 1755 WP_213659465.1 bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase -
JYG34_RS03300 (JYG34_03300) 743498..744103 - 606 WP_213659466.1 CDP-alcohol phosphatidyltransferase family protein -
JYG34_RS03305 (JYG34_03305) 744318..744500 + 183 WP_213659467.1 type II toxin-antitoxin system HicA family toxin Toxin
JYG34_RS03310 (JYG34_03310) 744557..744964 + 408 WP_213659468.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JYG34_RS03315 (JYG34_03315) 745005..745319 - 315 WP_213659469.1 putative quinol monooxygenase -
JYG34_RS03320 (JYG34_03320) 745519..746106 + 588 WP_213659470.1 NAD(P)H-dependent oxidoreductase -
JYG34_RS03325 (JYG34_03325) 746294..747190 + 897 WP_213659471.1 LysR family transcriptional regulator -
JYG34_RS03330 (JYG34_03330) 747310..748977 + 1668 WP_213659472.1 gamma-glutamyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6926.98 Da        Isoelectric Point: 11.2510

>T194905 WP_213659467.1 NZ_CP070982:744318-744500 [Pseudomonas entomophila]
MRSRDVIQLIEADGWYEVEVKGSHHQFRHPFKRGRVTVPHPKSDLPRGTAHSILKRAGLK

Download         Length: 183 bp

>T194905 NZ_CP094173:1617045-1617326 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTAAAGAAAGCGA
TGTTACAAGCATTGTTGATTGCCTCAAAGAGCAAAAACCACTCCAACAAAAGTATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGTTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14646.54 Da        Isoelectric Point: 4.7269

>AT194905 WP_213659468.1 NZ_CP070982:744557-744964 [Pseudomonas entomophila]
MKFPVVLHKDEGSDYGVIVPDVPGCFSAGFSVSQALDNVQEALALHFEGLVADGEALPQAQEVDVHVANPDYAGGVWAVV
EFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAALRELAVVH

Download         Length: 408 bp

>AT194905 NZ_CP094173:1616738-1617052 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAACACGATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGATTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References