Detailed information of TA system TA194903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 2125594..2126204
• Replicon: chromosome
• Accession: NZ_CP070981
• Organism: Pseudomonas rhodesiae strain DLA23

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2G0WYT7
• Locus tag: JYG38_RS09745
• Protein ID: WP_034096965.1
• Coordinates: 2125953..2126204 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JYG38_RS09740
• Protein ID: WP_167418647.1
• Coordinates: 2125594..2125956 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYG38_RS09720 (JYG38_09720)	2120860..2121690	+	831	WP_034137847.1	IclR family transcriptional regulator	-
JYG38_RS09725 (JYG38_09725)	2121919..2122749	+	831	WP_213633858.1	hypothetical protein	-
JYG38_RS09730 (JYG38_09730)	2123020..2124375	+	1356	WP_040268007.1	MATE family efflux transporter	-
JYG38_RS09735 (JYG38_09735)	2124417..2125589	+	1173	WP_034137850.1	MFS transporter	-
JYG38_RS09740 (JYG38_09740)	2125594..2125956	-	363	WP_167418647.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JYG38_RS09745 (JYG38_09745)	2125953..2126204	-	252	WP_034096965.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9497.05 Da
• Isoelectric Point: 10.0458

>T194903 WP_034096965.1 NZ_CP070981:c2126204-2125953 [Pseudomonas rhodesiae]
VSKNEKLLAKLLNEQMAFTWPELVTLLRRLGYTQIEGAGSRVKFDSGDPTAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Nucleotide

• Length: 252 bp

>T194903 NZ_CP094172:578146-578412 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCACTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTACTTGTTTATTTGGTGAAAGGTGATGAGCTTATTTTAGTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13188.05 Da
• Isoelectric Point: 6.9564

>AT194903 WP_167418647.1 NZ_CP070981:c2125956-2125594 [Pseudomonas rhodesiae]
VNNQLKYKGYIGSIEASLEDNCLFGKILFIKALISYEGKTVADLDAAFQAAVDDYLVTCQNLGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHFAELHPSA

Nucleotide

• Length: 363 bp

>AT194903 NZ_CP094172:577788-578165 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTG
GGGCGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGCTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Structures

Toxin

• AlphaFold DB: A0A2G0WYT7