Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 502025..502624 Replicon chromosome
Accession NZ_CP070981
Organism Pseudomonas rhodesiae strain DLA23

Toxin (Protein)


Gene name relE Uniprot ID A0A5C5P148
Locus tag JYG38_RS02165 Protein ID WP_034095668.1
Coordinates 502319..502624 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8I1E6D6
Locus tag JYG38_RS02160 Protein ID WP_034095667.1
Coordinates 502025..502315 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG38_RS02140 (JYG38_02140) 498436..500496 - 2061 WP_213632964.1 TonB-dependent copper receptor -
JYG38_RS02145 (JYG38_02145) 500589..500990 - 402 WP_034095664.1 DUF2946 domain-containing protein -
JYG38_RS02150 (JYG38_02150) 501002..501484 - 483 WP_034136693.1 copper chaperone PCu(A)C -
JYG38_RS02155 (JYG38_02155) 501532..501927 - 396 WP_094065078.1 DUF2946 domain-containing protein -
JYG38_RS02160 (JYG38_02160) 502025..502315 - 291 WP_034095667.1 putative addiction module antidote protein Antitoxin
JYG38_RS02165 (JYG38_02165) 502319..502624 - 306 WP_034095668.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JYG38_RS02170 (JYG38_02170) 503001..503735 - 735 WP_213632966.1 cobalt-precorrin-6A reductase -
JYG38_RS02175 (JYG38_02175) 503732..504937 - 1206 WP_213632968.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
JYG38_RS02180 (JYG38_02180) 505033..506322 + 1290 WP_276574130.1 precorrin-3B synthase -
JYG38_RS02185 (JYG38_02185) 506315..506941 + 627 WP_094065075.1 precorrin-8X methylmutase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 102 a.a.        Molecular weight: 11640.25 Da        Isoelectric Point: 5.8918

>T194902 WP_034095668.1 NZ_CP070981:c502624-502319 [Pseudomonas rhodesiae]
MTIEFNETIEFANWLEAVRDPFVKVRVVKRVRMAEAGNFGDCESVGDGVFEMRIHYGPGYRVYFTRRDEVVYLLLIGGDK
STQSRDIKRAKQIAINFGSEE

Download         Length: 306 bp

>T194902 NZ_CP094171:577240-577524 [Helicobacter pylori]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10404.99 Da        Isoelectric Point: 5.8124

>AT194902 WP_034095667.1 NZ_CP070981:c502315-502025 [Pseudomonas rhodesiae]
MSESFSRFDAAKYLKTPLEMAAYLETCFEDDAGDGLLIRTALNDIARAQGMTQVARDAGLGRESLYKALSSSGNPEFATI
MKVMKALGLKLHATVI

Download         Length: 291 bp

>AT194902 NZ_CP094171:576867-577259 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATAATAAAAGAGATTGTTGTTTT
GGGCATGAAACCCCAAACCTTGAAACGCAACAAGCCATGAGAGAAGCGTTAAATGGGGTTAATCTCACTCAAATTGATAG
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATAGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5C5P148


Antitoxin

Source ID Structure

References