Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 3882582..3883146 | Replicon | chromosome |
| Accession | NZ_CP070980 | ||
| Organism | Pseudomonas rhodesiae strain AAMF24 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A2G0X6W5 |
| Locus tag | JYG35_RS17505 | Protein ID | WP_034099058.1 |
| Coordinates | 3882859..3883146 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A2G0X669 |
| Locus tag | JYG35_RS17500 | Protein ID | WP_034099056.1 |
| Coordinates | 3882582..3882869 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JYG35_RS17460 (JYG35_17460) | 3877984..3878301 | - | 318 | WP_034099046.1 | transcriptional regulator | - |
| JYG35_RS17465 (JYG35_17465) | 3878298..3878642 | - | 345 | WP_034114384.1 | toxin | - |
| JYG35_RS17470 (JYG35_17470) | 3878765..3879568 | - | 804 | WP_034114382.1 | phage antirepressor KilAC domain-containing protein | - |
| JYG35_RS17475 (JYG35_17475) | 3879646..3879876 | - | 231 | WP_236238667.1 | DUF3077 domain-containing protein | - |
| JYG35_RS17480 (JYG35_17480) | 3879950..3880105 | - | 156 | WP_143506426.1 | Arc family DNA-binding protein | - |
| JYG35_RS17485 (JYG35_17485) | 3880250..3880681 | + | 432 | WP_052229582.1 | helix-turn-helix domain-containing protein | - |
| JYG35_RS17490 (JYG35_17490) | 3881170..3881802 | - | 633 | WP_143506428.1 | hypothetical protein | - |
| JYG35_RS17495 (JYG35_17495) | 3882003..3882476 | + | 474 | WP_034114380.1 | hypothetical protein | - |
| JYG35_RS17500 (JYG35_17500) | 3882582..3882869 | + | 288 | WP_034099056.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| JYG35_RS17505 (JYG35_17505) | 3882859..3883146 | + | 288 | WP_034099058.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JYG35_RS17510 (JYG35_17510) | 3883186..3883950 | - | 765 | WP_034099060.1 | KilA-N domain-containing protein | - |
| JYG35_RS17515 (JYG35_17515) | 3884063..3884281 | - | 219 | WP_034099062.1 | hypothetical protein | - |
| JYG35_RS17520 (JYG35_17520) | 3884304..3884612 | - | 309 | WP_034114377.1 | hypothetical protein | - |
| JYG35_RS26525 | 3884690..3884900 | - | 211 | Protein_3467 | hypothetical protein | - |
| JYG35_RS17525 (JYG35_17525) | 3885727..3885960 | + | 234 | WP_034099068.1 | Arc family DNA-binding protein | - |
| JYG35_RS17530 (JYG35_17530) | 3886112..3886459 | + | 348 | WP_034099069.1 | hypothetical protein | - |
| JYG35_RS26530 | 3886548..3886868 | + | 321 | WP_249745166.1 | hypothetical protein | - |
| JYG35_RS17535 (JYG35_17535) | 3886754..3887935 | + | 1182 | WP_249745106.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3869854..3890900 | 21046 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11017.87 Da Isoelectric Point: 10.2255
>T194900 WP_034099058.1 NZ_CP070980:3882859-3883146 [Pseudomonas rhodesiae]
MAAEYEVEWDPKALKELRKLDGTIRLQFLKKLQERQSGPRVPGDALHGMKDCYKIKLRGAGYRLVYRVEDERIVILVLAV
GKRERSSVYEQAGKR
MAAEYEVEWDPKALKELRKLDGTIRLQFLKKLQERQSGPRVPGDALHGMKDCYKIKLRGAGYRLVYRVEDERIVILVLAV
GKRERSSVYEQAGKR
Download Length: 288 bp
>T194900 NZ_CP094168:570259-570531 [Helicobacter pylori]
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACCTGAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGGCTAGGCAGTCATAGCGAGCTGTTTTAA
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACCTGAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGGCTAGGCAGTCATAGCGAGCTGTTTTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10290.83 Da Isoelectric Point: 4.4354
>AT194900 WP_034099056.1 NZ_CP070980:3882582-3882869 [Pseudomonas rhodesiae]
MQNILADVAVSVSELKKNPSSVLSGANGMPVAVLNHNRVMGYMVPANVYEAMVERLDELELVQLVKARLDAKETPVRVSL
DDLIGETEADIANGR
MQNILADVAVSVSELKKNPSSVLSGANGMPVAVLNHNRVMGYMVPANVYEAMVERLDELELVQLVKARLDAKETPVRVSL
DDLIGETEADIANGR
Download Length: 288 bp
>AT194900 NZ_CP094168:569961-570272 [Helicobacter pylori]
ATGCCTAATTCTCCCATCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAATATAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA
ATGCCTAATTCTCCCATCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAATATAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2G0X6W5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2G0X669 |