Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 890600..891193 Replicon chromosome
Accession NZ_CP070980
Organism Pseudomonas rhodesiae strain AAMF24

Toxin (Protein)


Gene name relE Uniprot ID A0A2G0W982
Locus tag JYG35_RS03840 Protein ID WP_040265967.1
Coordinates 890891..891193 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2G0W996
Locus tag JYG35_RS03835 Protein ID WP_040265965.1
Coordinates 890600..890887 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG35_RS03815 (JYG35_03815) 887010..889070 - 2061 WP_213548642.1 TonB-dependent copper receptor -
JYG35_RS03820 (JYG35_03820) 889164..889565 - 402 WP_034095664.1 DUF2946 domain-containing protein -
JYG35_RS03825 (JYG35_03825) 889577..890059 - 483 WP_047881390.1 copper chaperone PCu(A)C -
JYG35_RS03830 (JYG35_03830) 890107..890502 - 396 WP_099313077.1 DUF2946 domain-containing protein -
JYG35_RS03835 (JYG35_03835) 890600..890887 - 288 WP_040265965.1 putative addiction module antidote protein Antitoxin
JYG35_RS03840 (JYG35_03840) 890891..891193 - 303 WP_040265967.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JYG35_RS03845 (JYG35_03845) 891588..892322 - 735 WP_184315982.1 cobalt-precorrin-6A reductase -
JYG35_RS03850 (JYG35_03850) 892319..893524 - 1206 WP_169869050.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
JYG35_RS03855 (JYG35_03855) 893638..894909 + 1272 WP_283812481.1 precorrin-3B synthase -
JYG35_RS03860 (JYG35_03860) 894902..895528 + 627 WP_034095672.1 precorrin-8X methylmutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11709.40 Da        Isoelectric Point: 10.1888

>T194897 WP_040265967.1 NZ_CP070980:c891193-890891 [Pseudomonas rhodesiae]
MIQFKKSKHFQEWLDSLRSKPARARVLARLDNAQWGNFGDCEALGNGVFEMRIHYGPGYRVYFTRRGEVVYLLLIGGDKS
TQKRDIQRAKQIAEDFEKKE

Download         Length: 303 bp

>T194897 NZ_CP094165:611118-611399 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTAAAGAAAGCGA
TATTACAAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCACTCCAACAAAAGTATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTCAAGCCAAACTTGCTGTTGATTTATGAAGTCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10363.77 Da        Isoelectric Point: 4.4791

>AT194897 WP_040265965.1 NZ_CP070980:c890887-890600 [Pseudomonas rhodesiae]
MNEFTDFDVAEHLRTPEDMAEYLEACFEEDAGDGVLIRSALNNIARAQGMTQVARDAGLGRESLYKALSSSGNPEFATIM
KVMKALGLKLHATVI

Download         Length: 288 bp

>AT194897 NZ_CP094165:610811-611125 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAAGAGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G0W982

Antitoxin

Source ID Structure
AlphaFold DB A0A2G0W996

References