Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2992205..2993423 Replicon chromosome
Accession NZ_CP070978
Organism Burkholderia pyrrocinia strain Hargis

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JYG32_RS31560 Protein ID WP_213266214.1
Coordinates 2992205..2992786 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JYG32_RS31565 Protein ID WP_213266215.1
Coordinates 2992866..2993423 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG32_RS31545 (JYG32_31555) 2988475..2990499 - 2025 WP_213266212.1 MacB family efflux pump subunit -
JYG32_RS31550 (JYG32_31560) 2990502..2991695 - 1194 WP_213266213.1 efflux RND transporter periplasmic adaptor subunit -
JYG32_RS31555 (JYG32_31565) 2992060..2992149 - 90 Protein_2688 SAM-dependent methyltransferase -
JYG32_RS31560 (JYG32_31570) 2992205..2992786 - 582 WP_213266214.1 HD domain-containing protein Toxin
JYG32_RS31565 (JYG32_31575) 2992866..2993423 - 558 WP_213266215.1 helix-turn-helix transcriptional regulator Antitoxin
JYG32_RS31570 (JYG32_31580) 2993508..2994146 - 639 WP_213266216.1 hypothetical protein -
JYG32_RS31575 (JYG32_31585) 2994506..2995909 + 1404 WP_213266217.1 DUF308 domain-containing protein -
JYG32_RS31580 (JYG32_31590) 2996008..2996586 + 579 WP_213266218.1 hypothetical protein -
JYG32_RS31585 (JYG32_31595) 2996833..2997564 + 732 WP_213266219.1 ribonuclease T2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21308.89 Da        Isoelectric Point: 4.9532

>T194895 WP_213266214.1 NZ_CP070978:c2992786-2992205 [Burkholderia pyrrocinia]
MTPDTIHARLDFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRTLRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGQRA

Download         Length: 582 bp

>T194895 NZ_CP094163:617463-617729 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGACGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTAGTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20206.13 Da        Isoelectric Point: 10.7075

>AT194895 WP_213266215.1 NZ_CP070978:c2993423-2992866 [Burkholderia pyrrocinia]
MTASPLHTPPLGPQLKRWRALHRVKQSHAAELFGVGQSTISRWEAGLQQMSPDERTTAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLPMLLGTSLWRYATPEIVRMEAALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSRCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT194895 NZ_CP094163:617105-617482 [Helicobacter pylori]
ATGCCTAACTCTCCTACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCCATCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCGTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGACGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAAGGCGTTAGGTGTTGAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References