Detailed information of TA system TA194892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1000725..1001371
• Replicon: chromosome
• Accession: NZ_CP070978
• Organism: Burkholderia pyrrocinia strain Hargis

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JYG32_RS22565
• Protein ID: WP_174381992.1
• Coordinates: 1000725..1001132 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1K1MVH7
• Locus tag: JYG32_RS22570
• Protein ID: WP_072436899.1
• Coordinates: 1001129..1001371 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYG32_RS22545 (JYG32_22550)	996915..997097	+	183	WP_213267032.1	hypothetical protein	-
JYG32_RS22550 (JYG32_22555)	997150..998280	-	1131	WP_213267033.1	porin	-
JYG32_RS22555 (JYG32_22560)	998544..999122	+	579	WP_213267034.1	thioesterase family protein	-
JYG32_RS22560 (JYG32_22565)	999141..1000628	+	1488	WP_213267035.1	aldehyde dehydrogenase	-
JYG32_RS22565 (JYG32_22570)	1000725..1001132	-	408	WP_174381992.1	type II toxin-antitoxin system VapC family toxin	Toxin
JYG32_RS22570 (JYG32_22575)	1001129..1001371	-	243	WP_072436899.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JYG32_RS22575 (JYG32_22580)	1001632..1002315	+	684	WP_174381993.1	phospholipase	-
JYG32_RS22580 (JYG32_22585)	1002368..1003879	-	1512	WP_174381994.1	amino acid permease	-
JYG32_RS22585 (JYG32_22590)	1003983..1005389	-	1407	WP_213267036.1	aspartate ammonia-lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14956.11 Da
• Isoelectric Point: 6.4921

>T194892 WP_174381992.1 NZ_CP070978:c1001132-1000725 [Burkholderia pyrrocinia]
MKFLLDTNAVIAILKGEPAMLAKLRAHRPADFGIPAIVAHELYYGAYKSRRVAANLARVEGLQFEVVSFDAEDAQHAGEI
RAHWTAAGTPIGPYDALIAGQARARRLVLVTHDMREFERVPELQIEDWLAGAHEN

Nucleotide

• Length: 408 bp

>T194892 NZ_CP094157:c1083749-1083477 [Helicobacter pylori]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAATGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGAACCCAAATACAAAGACCACCCGCTCAAAGGCGGTTTAA
AAGATTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGACTAGGCAGTCATAGCGAGTTGTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8985.19 Da
• Isoelectric Point: 4.7483

>AT194892 WP_072436899.1 NZ_CP070978:c1001371-1001129 [Burkholderia pyrrocinia]
MDIAKIFKHGGSQAVRLPKDFRFETTEVRIRRHGASVILEPVPQDWAWLTPLIGPVDADFEAAATTQPDVQERPGLDVFE

Nucleotide

• Length: 243 bp

>AT194892 NZ_CP094157:c1084047-1083736 [Helicobacter pylori]
ATGCCTAACACCACCGCAGAAAAAGACTACACAAAATACAGCGAAAAACAGCTTGTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CACTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGAAAGGGCTGAAGATACCAAGAACCAC
CTTTGTTTTAAAAGCATAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1K1MVH7