Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 329443..330082 Replicon chromosome
Accession NZ_CP070978
Organism Burkholderia pyrrocinia strain Hargis

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JYG32_RS19580 Protein ID WP_249744894.1
Coordinates 329666..330082 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JYG32_RS19575 Protein ID WP_213266610.1
Coordinates 329443..329679 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG32_RS19560 (JYG32_19560) 325184..326770 + 1587 WP_283842736.1 FadD3 family acyl-CoA ligase -
JYG32_RS19565 (JYG32_19565) 326803..327576 + 774 WP_213266609.1 SDR family oxidoreductase -
JYG32_RS19570 (JYG32_19570) 328401..329030 + 630 WP_174382095.1 hypothetical protein -
JYG32_RS19575 (JYG32_19575) 329443..329679 + 237 WP_213266610.1 DNA-binding protein Antitoxin
JYG32_RS19580 (JYG32_19580) 329666..330082 + 417 WP_249744894.1 type II toxin-antitoxin system VapC family toxin Toxin
JYG32_RS19585 (JYG32_19585) 330216..331358 - 1143 WP_249744821.1 trypsin-like serine protease -
JYG32_RS19590 (JYG32_19590) 332212..333108 + 897 WP_213266612.1 VOC family protein -
JYG32_RS19595 (JYG32_19595) 333118..334020 + 903 WP_174382076.1 CoA transferase subunit A -
JYG32_RS19600 (JYG32_19600) 334031..334828 + 798 WP_174382075.1 ketoacid CoA transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15282.49 Da        Isoelectric Point: 8.6233

>T194891 WP_249744894.1 NZ_CP070978:329666-330082 [Burkholderia pyrrocinia]
VFLIDTNVISEIRKGKRANGGVRAFFREARNDGSSLYLSVVTVSELRRGVEMIRRRGDSQQASTLDTWLAALMSDYAPNI
LPIDIDVGQLWGHLRVPHPEHALDKLIAATALINDLTVVTRNVGDFAKTGVRLVNPFD

Download         Length: 417 bp

>T194891 NZ_CP094157:c488846-488577 [Helicobacter pylori]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAAAACACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCGCAAGTTTATAAAGCGATCAATAAACTTTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8624.69 Da        Isoelectric Point: 5.8065

>AT194891 WP_213266610.1 NZ_CP070978:329443-329679 [Burkholderia pyrrocinia]
MANLLVRNVDASIVQSLREQAAANGRSAEAEHRAILADALGRPKRRTFAQVLMSMPDVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp

>AT194891 NZ_CP094157:c489210-488827 [Helicobacter pylori]
ATGCCTAACACCACCGCAGAAAAAGACTACACAAAATACAGCGAAAAACAGCTTGTTAATCTCATGAATAAGAAAGAACA
AGAAATAGAAAAGCTAAAAAGGGATAGGGCGTATCTTGAAAAAAAAATGGCTAAAGAGCTAGAGAAAAAAGATAAAGGTT
TCACTATCAAGTTAGAAGAATTGAATAAAATCTTACAAGAGATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAG
ATTCCAAATATTGAAACGCAACAAGCCATGAGAGAAGCGTTAAATGGAATCAATCTCACTCAAATTGATAGTTTAGATGA
TCTTACAAACGAGTTAAAAAGAGAAAATAGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References