Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 70997..72827 Replicon chromosome
Accession NZ_CP070978
Organism Burkholderia pyrrocinia strain Hargis

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag JYG32_RS18470 Protein ID WP_213266464.1
Coordinates 70997..71893 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag JYG32_RS18475 Protein ID WP_213266465.1
Coordinates 71973..72827 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG32_RS18440 (JYG32_18440) 66375..67454 - 1080 WP_174384195.1 porin -
JYG32_RS18445 (JYG32_18445) 67902..68219 + 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
JYG32_RS18450 (JYG32_18450) 68221..68532 + 312 WP_034180372.1 hypothetical protein -
JYG32_RS18455 (JYG32_18455) 68588..69658 + 1071 WP_174384194.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
JYG32_RS18460 (JYG32_18460) 69651..70421 + 771 WP_213266463.1 SDR family oxidoreductase -
JYG32_RS18465 (JYG32_18465) 70451..70978 + 528 WP_174384192.1 cupin domain-containing protein -
JYG32_RS18470 (JYG32_18470) 70997..71893 + 897 WP_213266464.1 alpha/beta fold hydrolase Toxin
JYG32_RS18475 (JYG32_18475) 71973..72827 + 855 WP_213266465.1 IclR family transcriptional regulator Antitoxin
JYG32_RS18480 (JYG32_18480) 72824..73621 + 798 WP_174382122.1 SDR family oxidoreductase -
JYG32_RS18485 (JYG32_18485) 73614..75281 + 1668 WP_213266466.1 thiamine pyrophosphate-binding protein -
JYG32_RS18490 (JYG32_18490) 75274..76089 + 816 WP_213266467.1 aspartate dehydrogenase -
JYG32_RS18495 (JYG32_18495) 76170..77660 + 1491 WP_213266468.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(142-265)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30548.75 Da        Isoelectric Point: 8.0625

>T194890 WP_213266464.1 NZ_CP070978:70997-71893 [Burkholderia pyrrocinia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARAMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDTQRGLG

Download         Length: 897 bp

>T194890 NZ_CP094157:18853-19617 [Helicobacter pylori]
ATGGAAACTAAAGAAGAAGATAAAGATAAAAAGCTAGAAGAAATGATTGTATCGCTGTGTGAAAAGGGGGATTTGTCTAG
CCAAACAGATCAAATCATCAAAGATCTCAAAGAAATCTATCAAGGAGAATACAGGCATAAATACTCAAAAATTACAACTA
TTATTTTAAATTCCACAAGGGATAGAGAGCAAGCCTTTATGACGCTCACACAAAATATAAGGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACGCAATACATAACCATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTACCGTTTGGTTTTTGTTATGGCTTT
TATGGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTGCAATTCTATTTGTGATTGGTTTTGTG
GGAGAATTGCATATAATACAGAGATTAGTTTCTAAATATCTTTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31228.77 Da        Isoelectric Point: 6.9861

>AT194890 WP_213266465.1 NZ_CP070978:71973-72827 [Burkholderia pyrrocinia]
MSEPLQQEAENGKAEAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLKELRALYPQGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVPR
PEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT194890 NZ_CP094157:18426-18863 [Helicobacter pylori]
ATGGTTAATGCTTTGGAGCTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGTAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGAGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCTATTGACAAACCCAAAGAAGAATCGCTC
TCACAAAATCTTAGAAAAGATGAACTTGAAACCATCAATCGCTCCATAGAAAAATGCAACAAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGTAAAGATT
TGATCAGACAAGAAGCCAAACAAACAAATGGAAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References