194877

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1363946..1364862 Replicon chromosome
Accession NZ_CP070976
Organism Bacillus halotolerans strain MBH1

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7G7U9Y2
Locus tag JYG31_RS07025 Protein ID WP_024121091.1
Coordinates 1364116..1364862 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7G7U9Y3
Locus tag JYG31_RS07020 Protein ID WP_024121090.1
Coordinates 1363946..1364116 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG31_RS06985 (1360814) 1360814..1361143 + 330 WP_024121082.1 XkdW family protein -
JYG31_RS06990 (1361140) 1361140..1361304 + 165 WP_185848046.1 XkdX family protein -
JYG31_RS06995 (1361348) 1361348..1362187 + 840 WP_185848045.1 phage portal protein -
JYG31_RS07000 (1362243) 1362243..1362512 + 270 WP_024121085.1 hemolysin XhlA family protein -
JYG31_RS07005 (1362524) 1362524..1362787 + 264 WP_024121086.1 phage holin -
JYG31_RS07010 (1362800) 1362800..1363689 + 890 Protein_1328 N-acetylmuramoyl-L-alanine amidase -
JYG31_RS07015 (1363725) 1363725..1363862 - 138 WP_125825426.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
JYG31_RS07020 (1363946) 1363946..1364116 - 171 WP_024121090.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
JYG31_RS07025 (1364116) 1364116..1364862 - 747 WP_024121091.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
JYG31_RS07030 (1364970) 1364970..1365971 - 1002 WP_024121092.1 inorganic phosphate transporter -
JYG31_RS07035 (1365984) 1365984..1366601 - 618 WP_010333926.1 DUF47 domain-containing protein -
JYG31_RS07040 (1366878) 1366878..1368194 - 1317 WP_099042852.1 serine/threonine exchanger -
JYG31_RS07045 (1368589) 1368589..1369539 + 951 WP_024121094.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1330678..1407619 76941


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29076.48 Da        Isoelectric Point: 4.4986

>T194877 WP_024121091.1 NZ_CP070976:c1364862-1364116 [Bacillus halotolerans]
MLLFFQIMVWCTMAALGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQSDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T194877 NZ_CP094145:18357-19121 [Helicobacter pylori]
ATGGAAATTAAAGAAGAGAATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGTTGTGCGAAGAGGGGGATTTGTCTAG
TCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
CTATTTTAAATTCTACAAGGGATAAAGAGCAAGCCTTTATGACGCTCACACAAAATATAAAGACGCTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGAAGATGAACTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACACAATACATAACAATTCTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTGTTTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAGAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAATTTATTTTTTGGTTTAATCTAATGGTTACAATTCTATTTGTGATTGGTTTTGTG
GGAGAATTGCATATAATACAAAGATTAGCTTCTAAATATTTTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6578.62 Da        Isoelectric Point: 10.9236

>AT194877 WP_024121090.1 NZ_CP070976:c1364116-1363946 [Bacillus halotolerans]
MENAFQNGCHPRAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT194877 NZ_CP094145:17930-18367 [Helicobacter pylori]
ATGGTCAATGCTTTGGAATTAGCAAAATATATTCTTAAGCATTCCAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GACCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCGCAAAATCTTAGAAAAGATGAACTTGAAACCATCAATCGCTCCATAGAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAGTCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCGAATGGAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G7U9Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7U9Y3

References