Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 531169..531805 | Replicon | chromosome |
| Accession | NZ_CP070976 | ||
| Organism | Bacillus halotolerans strain MBH1 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | JYG31_RS02655 | Protein ID | WP_003156187.1 |
| Coordinates | 531455..531805 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | JYG31_RS02650 | Protein ID | WP_003225183.1 |
| Coordinates | 531169..531450 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JYG31_RS02630 (527524) | 527524..528123 | - | 600 | WP_024120294.1 | rhomboid family intramembrane serine protease | - |
| JYG31_RS02635 (528218) | 528218..528583 | + | 366 | WP_024120295.1 | holo-ACP synthase | - |
| JYG31_RS02640 (528749) | 528749..529765 | + | 1017 | WP_082687822.1 | outer membrane lipoprotein carrier protein LolA | - |
| JYG31_RS02645 (529882) | 529882..531051 | + | 1170 | WP_103671960.1 | alanine racemase | - |
| JYG31_RS02650 (531169) | 531169..531450 | + | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| JYG31_RS02655 (531455) | 531455..531805 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| JYG31_RS02660 (531920) | 531920..532744 | + | 825 | WP_081638235.1 | RsbT co-antagonist protein RsbRA | - |
| JYG31_RS02665 (532749) | 532749..533114 | + | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
| JYG31_RS02670 (533118) | 533118..533519 | + | 402 | WP_024120299.1 | serine/threonine-protein kinase RsbT | - |
| JYG31_RS02675 (533531) | 533531..534538 | + | 1008 | WP_024120300.1 | phosphoserine phosphatase RsbU | - |
| JYG31_RS02680 (534599) | 534599..534928 | + | 330 | WP_024120301.1 | anti-sigma factor antagonist RsbV | - |
| JYG31_RS02685 (534925) | 534925..535407 | + | 483 | WP_024120302.1 | anti-sigma B factor RsbW | - |
| JYG31_RS02690 (535373) | 535373..536161 | + | 789 | WP_024120303.1 | RNA polymerase sigma factor SigB | - |
| JYG31_RS02695 (536161) | 536161..536760 | + | 600 | WP_024120304.1 | phosphoserine phosphatase RsbX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T194876 WP_003156187.1 NZ_CP070976:531455-531805 [Bacillus halotolerans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T194876 NZ_CP094144:484231-484512 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTAAAGAAAGCGA
TGTTACGAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCACTCCAACAAAAACATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGTTGATGGAATGCCATGTTAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTAAAGAAAGCGA
TGTTACGAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCACTCCAACAAAAACATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGTTGATGGAATGCCATGTTAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT194876 WP_003225183.1 NZ_CP070976:531169-531450 [Bacillus halotolerans]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT194876 NZ_CP094144:483924-484238 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTATTCGCAATATAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGTGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGATTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA
ATGTCAAATATTATTACAGATTATTCGCAATATAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGTGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGATTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|