194873

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 40272..40915 Replicon plasmid p706-2
Accession NZ_CP070972
Organism Klebsiella pneumoniae strain JS706

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag JXZ99_RS27185 Protein ID WP_001044770.1
Coordinates 40499..40915 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag JXZ99_RS27180 Protein ID WP_001261282.1
Coordinates 40272..40502 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JXZ99_RS27145 35495..36274 - 780 WP_013214009.1 site-specific integrase -
JXZ99_RS27150 36458..37462 - 1005 WP_011977814.1 hypothetical protein -
JXZ99_RS27155 37492..37695 - 204 WP_011977813.1 hypothetical protein -
JXZ99_RS27160 37741..38262 - 522 WP_013214008.1 hypothetical protein -
JXZ99_RS27165 38320..38712 - 393 WP_011977811.1 hypothetical protein -
JXZ99_RS27170 38749..39693 - 945 WP_011977810.1 hypothetical protein -
JXZ99_RS27175 39854..40315 - 462 WP_014343465.1 hypothetical protein -
JXZ99_RS27180 40272..40502 + 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JXZ99_RS27185 40499..40915 + 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
JXZ99_RS27190 40989..42551 + 1563 WP_004206609.1 AAA family ATPase -
JXZ99_RS27195 42536..43558 + 1023 WP_000361404.1 helicase UvrD -
JXZ99_RS27200 43814..44511 + 698 Protein_60 IS1 family transposase -
JXZ99_RS27205 44540..44812 + 273 Protein_61 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1C - 1..106126 106126


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T194873 WP_001044770.1 NZ_CP070972:40499-40915 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T194873 NZ_CP094143:c525815-525534 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTGTAAGCATTGTTGATCGCCTCAAAGAGCAAAAACCACTCCAACAAAAATATTGCGACCATGCATTAGGTGGCAATC
TTAAAGAGTTGAGGGAATGCCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT194873 WP_001261282.1 NZ_CP070972:40272-40502 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT194873 NZ_CP094143:c526122-525808 [Helicobacter pylori]
GTGTCAAATATTATTACAGATTATTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAACAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References