Detailed information of TA system TA194869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4500743..4502424
• Replicon: chromosome
• Accession: NZ_CP070970
• Organism: Klebsiella pneumoniae strain JS706

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: JXZ99_RS22200
• Protein ID: WP_002885155.1
• Coordinates: 4501507..4502424 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W8UPQ8
• Locus tag: JXZ99_RS22195
• Protein ID: WP_004151732.1
• Coordinates: 4500743..4501501 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JXZ99_RS22180	4496593..4497279	-	687	WP_004151733.1	sel1 repeat family protein	-
JXZ99_RS22185	4497509..4499656	-	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
JXZ99_RS22190	4499929..4500657	+	729	WP_002885152.1	response regulator transcription factor	-
JXZ99_RS22195	4500743..4501501	+	759	WP_004151732.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JXZ99_RS22200	4501507..4502424	+	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JXZ99_RS22205	4502549..4503556	-	1008	WP_004151731.1	carbohydrate kinase family protein	-
JXZ99_RS22210	4503631..4504572	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JXZ99_RS22215	4504603..4505601	-	999	WP_002885172.1	ribose ABC transporter permease	-
JXZ99_RS22220	4505598..4507118	-	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T194869 WP_002885155.1 NZ_CP070970:4501507-4502424 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T194869 NZ_CP094140:611649-611915 [Helicobacter pylori]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTAGATCCCCAATTTAAAGATCATGCTTTAAAGGGAAAGTGGA
AGCCTTATAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTGATTTTGTTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28564.92 Da
• Isoelectric Point: 10.0870

>AT194869 WP_004151732.1 NZ_CP070970:4500743-4501501 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT194869 NZ_CP094140:611993-612304 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATTAAAAAAGCCCTCCAATTTAAAG
CACTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGAGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A0H3GQB5