194868

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4177749..4178374 Replicon chromosome
Accession NZ_CP070970
Organism Klebsiella pneumoniae strain JS706

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JXZ99_RS20690 Protein ID WP_002882817.1
Coordinates 4177991..4178374 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JXZ99_RS20685 Protein ID WP_004150355.1
Coordinates 4177749..4177991 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JXZ99_RS20660 4173740..4174339 + 600 WP_004151865.1 glucose-1-phosphatase -
JXZ99_RS20665 4174333..4175193 + 861 WP_002882807.1 virulence factor BrkB family protein -
JXZ99_RS20670 4175190..4175627 + 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JXZ99_RS20675 4175672..4176613 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JXZ99_RS20680 4176627..4177544 - 918 WP_002882812.1 alpha/beta hydrolase -
JXZ99_RS20685 4177749..4177991 + 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JXZ99_RS20690 4177991..4178374 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JXZ99_RS20695 4178548..4179477 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JXZ99_RS20700 4179474..4180109 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JXZ99_RS20705 4180106..4181008 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T194868 WP_002882817.1 NZ_CP070970:4177991-4178374 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T194868 NZ_CP094140:611649-611915 [Helicobacter pylori]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTAGATCCCCAATTTAAAGATCATGCTTTAAAGGGAAAGTGGA
AGCCTTATAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTGATTTTGTTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT194868 WP_004150355.1 NZ_CP070970:4177749-4177991 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT194868 NZ_CP094140:611291-611668 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTGCACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGACAAAAGGGATCAAAACT
TTAAAGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAGAGAAAAAAGGCGTTAGGTGTTAAAACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References