194864

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3227472..3228129 Replicon chromosome
Accession NZ_CP070970
Organism Klebsiella pneumoniae strain JS706

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JXZ99_RS15925 Protein ID WP_002916310.1
Coordinates 3227472..3227882 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JXZ99_RS15930 Protein ID WP_002916312.1
Coordinates 3227863..3228129 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JXZ99_RS15905 3223472..3225205 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
JXZ99_RS15910 3225211..3225924 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JXZ99_RS15915 3225947..3226843 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JXZ99_RS15920 3226944..3227465 + 522 WP_002916308.1 flavodoxin FldB -
JXZ99_RS15925 3227472..3227882 - 411 WP_002916310.1 protein YgfX Toxin
JXZ99_RS15930 3227863..3228129 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JXZ99_RS15935 3228375..3229358 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JXZ99_RS15940 3229509..3230168 - 660 WP_002916317.1 hemolysin III family protein -
JXZ99_RS15945 3230332..3230643 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
JXZ99_RS15950 3230693..3231421 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JXZ99_RS15955 3231540..3232973 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T194864 WP_002916310.1 NZ_CP070970:c3227882-3227472 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T194864 NZ_CP094138:576131-576397 [Helicobacter pylori]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCCCAATTTCAAGATCATGCTTTGAAAGGAAAGTGGA
AACCTTTTAAGGAATGCCATATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT194864 WP_002916312.1 NZ_CP070970:c3228129-3227863 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT194864 NZ_CP094138:575773-576150 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAGCTTAATCAATCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGTTTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References