194854

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 37930..38549 Replicon chromosome
Accession NZ_CP070970
Organism Klebsiella pneumoniae strain JS706

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JXZ99_RS00210 Protein ID WP_002892050.1
Coordinates 37930..38148 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JXZ99_RS00215 Protein ID WP_002892066.1
Coordinates 38175..38549 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JXZ99_RS00175 33977..34240 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
JXZ99_RS00180 34240..34380 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JXZ99_RS00185 34377..35075 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
JXZ99_RS00190 35176..36627 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JXZ99_RS00195 36602..37072 - 471 WP_002892026.1 YlaC family protein -
JXZ99_RS00200 37093..37233 + 141 WP_004147370.1 hypothetical protein -
JXZ99_RS00205 37205..37771 - 567 WP_002892030.1 maltose O-acetyltransferase -
JXZ99_RS00210 37930..38148 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JXZ99_RS00215 38175..38549 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JXZ99_RS00220 39035..42181 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JXZ99_RS00225 42204..43397 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T194854 WP_002892050.1 NZ_CP070970:c38148-37930 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T194854 NZ_CP094131:581891-582157 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAGAAAGAACCGCTAGACCCACAATTTAAAGATCATGCTTTAAAAGGCAATTGGA
AGCCTTTTAGGGAATGCCATATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTAGTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT194854 WP_002892066.1 NZ_CP070970:c38549-38175 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT194854 NZ_CP094131:581533-581910 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTT
GATCATGAAACCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGAGCTTTGGGTGTTGAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References