Detailed information of TA system TA194851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-AbrB
• Location: 3179814..3180351
• Replicon: chromosome
• Accession: NZ_CP070968
• Organism: Brevundimonas sp. CS1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: JX001_RS15520
• Protein ID: WP_205681698.1
• Coordinates: 3180016..3180351 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: JX001_RS15515
• Protein ID: WP_205681697.1
• Coordinates: 3179814..3180029 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JX001_RS15500	3176514..3177296	-	783	WP_205681694.1	ZIP family metal transporter	-
JX001_RS15505	3177361..3178518	+	1158	WP_205681695.1	glutamate 5-kinase	-
JX001_RS15510	3178515..3179777	+	1263	WP_205681696.1	glutamate-5-semialdehyde dehydrogenase	-
JX001_RS15515	3179814..3180029	+	216	WP_205681697.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
JX001_RS15520	3180016..3180351	+	336	WP_205681698.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
JX001_RS15525	3180410..3182824	-	2415	WP_205681699.1	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family	-
JX001_RS15530	3183057..3184484	+	1428	WP_205681700.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-105)

Antitoxin

• PrlF antitoxin (4-52)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12143.81 Da
• Isoelectric Point: 5.8333

>T194851 WP_205681698.1 NZ_CP070968:3180016-3180351 [Brevundimonas sp. CS1]
MPDFERGDVVRVPFPYTDRSTRQHRPALVVSDGPLGDDGRLVWVVMITSADNRSWADDVPLGDSYSEAGLPAPSVVRPAK
IATIDPAVATRLGRIDAERLARTMTVMRANL

Nucleotide

• Length: 336 bp

>T194851 NZ_CP094128:580646-580912 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCACTAGATCCACAATTTAAAGATCATGCCTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAACTGATATTTTGCTTGTGTATTTAGTGAGAGATGATGAGCTTATTTTAGTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7965.94 Da
• Isoelectric Point: 4.7107

>AT194851 WP_205681697.1 NZ_CP070968:3179814-3180029 [Brevundimonas sp. CS1]
MIKSRLTSKAQTTIPQAVRAALSLQDGDELQYDLDGDRVILRKVRRAPVEDPFAAFDEWDSDADRKAYAGL

Nucleotide

• Length: 216 bp

>AT194851 NZ_CP094128:580288-580665 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTACAGCGATGAAAGAAAAAGGGCTTTGGGTGTTGAAACTCAACCTTAA