Detailed information of TA system TA194849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relE/YoeB-RelB
• Location: 3108430..3108944
• Replicon: chromosome
• Accession: NZ_CP070968
• Organism: Brevundimonas sp. CS1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JX001_RS15120
• Protein ID: WP_205681637.1
• Coordinates: 3108684..3108944 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6G6RK27
• Locus tag: JX001_RS15115
• Protein ID: WP_039244788.1
• Coordinates: 3108430..3108687 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JX001_RS15085	3103514..3103732	+	219	WP_039244779.1	helix-turn-helix transcriptional regulator	-
JX001_RS15090	3103930..3104346	+	417	WP_205681634.1	DoxX family protein	-
JX001_RS15095	3104525..3105007	+	483	WP_039244783.1	MerR family DNA-binding transcriptional regulator	-
JX001_RS15100	3105011..3106795	+	1785	WP_205681635.1	acyl-CoA dehydrogenase C-terminal domain-containing protein	-
JX001_RS15105	3106961..3108124	+	1164	WP_205683215.1	acyl-CoA dehydrogenase family protein	-
JX001_RS15110	3108171..3108386	+	216	WP_205681636.1	hypothetical protein	-
JX001_RS15115	3108430..3108687	+	258	WP_039244788.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JX001_RS15120	3108684..3108944	+	261	WP_205681637.1	Txe/YoeB family addiction module toxin	Toxin
JX001_RS15125	3108941..3109660	+	720	WP_205681638.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
JX001_RS15130	3109796..3111157	+	1362	WP_205681639.1	glutamate--cysteine ligase	-
JX001_RS15135	3111154..3111897	-	744	WP_205681640.1	hypothetical protein	-
JX001_RS15140	3112007..3113578	+	1572	WP_205681641.1	response regulator	-
JX001_RS15145	3113633..3113887	+	255	WP_205681642.1	type II toxin-antitoxin system ParD family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10571.04 Da
• Isoelectric Point: 9.0388

>T194849 WP_205681637.1 NZ_CP070968:3108684-3108944 [Brevundimonas sp. CS1]
MKLTFQTYGWEDYLHWQDHDRKMLRKLNRLIIECQRTPFSGTGKPEPLKGDFAGWWSRRIDQEHRLVYRVTDDALLIAQC
RYHYDR

Nucleotide

• Length: 261 bp

>T194849 NZ_CP094124:502603-502884 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTACGAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTAAGTGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTTAAGCCAAACTTGCTGTTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9348.50 Da
• Isoelectric Point: 4.3566

>AT194849 WP_039244788.1 NZ_CP070968:3108430-3108687 [Brevundimonas sp. CS1]
MNAMSVTELRKNLAAAIDRVTADHDYTIITREGGKPAAVLMSLEDFASWQETEYLLRSPANAARLREAISELDAGGGQVR
ELIEE

Nucleotide

• Length: 258 bp

>AT194849 NZ_CP094124:502296-502610 [Helicobacter pylori]
GTGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTCTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A6G6RK27