Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1570307..1571964 Replicon chromosome
Accession NZ_CP070968
Organism Brevundimonas sp. CS1

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag JX001_RS07685 Protein ID WP_161638699.1
Coordinates 1570307..1571608 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag JX001_RS07690 Protein ID WP_161638700.1
Coordinates 1571605..1571964 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JX001_RS07645 1565535..1565927 + 393 WP_205682968.1 hypothetical protein -
JX001_RS07650 1565924..1566208 + 285 WP_161638692.1 hypothetical protein -
JX001_RS07655 1566263..1567231 + 969 WP_205682969.1 arsenic resistance protein -
JX001_RS07660 1567285..1567620 + 336 WP_183204371.1 metalloregulator ArsR/SmtB family transcription factor -
JX001_RS07665 1567628..1568053 + 426 WP_205682970.1 arsenate reductase (glutaredoxin) -
JX001_RS07670 1568050..1569129 + 1080 WP_205682971.1 ACR3 family arsenite efflux transporter -
JX001_RS07675 1569129..1569545 + 417 WP_205682972.1 GNAT family N-acetyltransferase -
JX001_RS07680 1569545..1570297 + 753 WP_161638698.1 arsenical resistance protein ArsH -
JX001_RS07685 1570307..1571608 - 1302 WP_161638699.1 HipA domain-containing protein Toxin
JX001_RS07690 1571605..1571964 - 360 WP_161638700.1 helix-turn-helix domain-containing protein Antitoxin
JX001_RS07695 1572168..1574102 - 1935 WP_205682973.1 FTR1 family protein -
JX001_RS07700 1574144..1574623 - 480 WP_205682974.1 MerR family DNA-binding protein -
JX001_RS07705 1574696..1575346 + 651 WP_205682975.1 cation transporter -
JX001_RS07710 1575343..1575996 + 654 WP_205682976.1 methyltransferase domain-containing protein -
JX001_RS07715 1576102..1576455 + 354 WP_205682977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(170-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 47440.63 Da        Isoelectric Point: 6.6172

>T194848 WP_161638699.1 NZ_CP070968:c1571608-1570307 [Brevundimonas sp. CS1]
MTTVAEVRLWGRRIGAVSLEDGAEVAAFAYDPAFAGSGIQVAPLTMPLGAQVFSFPGLNRESFHGLPGLLADALPDKYGN
TLIDAWLATQGRTPESFNAVERLCYTGARGMGALEFAPAVGPRPRKAARIQIDALVELASEVLSHRNDLQASFADSKKAD
ALREILRVGTSAGGARAKAVIAWNAATNEVRSGQVEAGDGFDYWLLKFDGVKNNKDRELADPEGYGAVEYAYARMAAAAG
VQVAECRLLEEGGRRHFMTKRFDRLPGGGKLHMQSLAALAHYDFCDPNAYAYEQAFLVIRQLGLPMAAIEEQYRRMVFNI
IARNQDDHVKNIAFLMDRSGAWSLSPAYDITWSYNPTGLWTARHQMAMNGKRDGFTLDDFDASARTASINARRARAIVQE
VRDAVARWPEFADAASVGEDWRKSIDPSLRTTL

Download         Length: 1302 bp

>T194848 NZ_CP094122:633931-634203 [Helicobacter pylori]
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATACAAAGACCACCCGCTCAAAGGCACTTTAA
AAGATTTTAGGGAATGCCACCTGAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGACTAGGCAGCCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13150.80 Da        Isoelectric Point: 5.9169

>AT194848 WP_161638700.1 NZ_CP070968:c1571964-1571605 [Brevundimonas sp. CS1]
MKITNLTTDDVALAEFGRRMADARLTRGMTQAQFAQAAGVSKRTIERLEDGGSVQVANLVRCLRALDRLEGLERLLPETP
PNPIDLLERHGKTRQRARPDADEGRDAGAAAPWTWGDEQ

Download         Length: 360 bp

>AT194848 NZ_CP094122:633633-633944 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCACTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References