Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 936084..936884 Replicon chromosome
Accession NZ_CP070964
Organism Staphylococcus sp. SB1-57

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag JX000_RS04720 Protein ID WP_107533115.1
Coordinates 936711..936884 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag JX000_RS04715 Protein ID WP_002452098.1
Coordinates 936084..936683 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JX000_RS04695 931869..933329 + 1461 WP_206140939.1 ABC transporter permease subunit -
JX000_RS04700 933322..934044 + 723 WP_206140940.1 ATP-binding cassette domain-containing protein -
JX000_RS04705 934302..935432 + 1131 WP_124227924.1 tRNA epoxyqueuosine(34) reductase QueG -
JX000_RS04710 935433..935903 + 471 WP_002452097.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
JX000_RS04715 936084..936683 + 600 WP_002452098.1 glucosamine-6-phosphate isomerase Antitoxin
JX000_RS04720 936711..936884 + 174 WP_107533115.1 hypothetical protein Toxin
JX000_RS04725 937044..937436 + 393 WP_002452100.1 hypothetical protein -
JX000_RS04730 937591..938976 + 1386 WP_107533114.1 class II fumarate hydratase -
JX000_RS04735 939036..939866 - 831 WP_049425061.1 RluA family pseudouridine synthase -
JX000_RS04740 940044..941156 + 1113 WP_002452103.1 GAF domain-containing sensor histidine kinase -
JX000_RS04745 941177..941800 + 624 WP_002452104.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6686.02 Da        Isoelectric Point: 3.8863

>T194843 WP_107533115.1 NZ_CP070964:936711-936884 [Staphylococcus sp. SB1-57]
MTQNKDSRTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEDKLNQSHDSEVRSDLD

Download         Length: 174 bp

>T194843 NZ_CP094120:c153701-153420 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTACAAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCGCTCCAACAAAAGTATTGCGACCATGCCTTAAGTGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTTAAGCCAAACTTGCTGTTGATTTATGAAGTCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22575.46 Da        Isoelectric Point: 4.8492

>AT194843 WP_002452098.1 NZ_CP070964:936084-936683 [Staphylococcus sp. SB1-57]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDENQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDESGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT194843 NZ_CP094120:c154008-153694 [Helicobacter pylori]
GTGTCAAATATTATTACAGATTACTCACAATACAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATG
GCTTAAGGCAGAAAGGGATAAAAACAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAGG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAAATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References