Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 792075..792604 Replicon chromosome
Accession NZ_CP070964
Organism Staphylococcus sp. SB1-57

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag JX000_RS03885 Protein ID WP_002451625.1
Coordinates 792242..792604 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag JX000_RS03880 Protein ID WP_002451626.1
Coordinates 792075..792245 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JX000_RS03855 787900..788373 + 474 WP_002451631.1 PH domain-containing protein -
JX000_RS03860 788366..789892 + 1527 WP_206140904.1 PH domain-containing protein -
JX000_RS03865 789879..790376 + 498 WP_002451629.1 PH domain-containing protein -
JX000_RS03870 790409..790783 + 375 WP_206140905.1 holo-ACP synthase -
JX000_RS03875 790835..791983 + 1149 WP_002451627.1 alanine racemase -
JX000_RS03880 792075..792245 + 171 WP_002451626.1 hypothetical protein Antitoxin
JX000_RS03885 792242..792604 + 363 WP_002451625.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JX000_RS03890 792931..793932 + 1002 WP_075778711.1 PP2C family protein-serine/threonine phosphatase -
JX000_RS03895 794027..794353 + 327 WP_002466754.1 anti-sigma factor antagonist -
JX000_RS03900 794355..794834 + 480 WP_206140906.1 anti-sigma B factor RsbW -
JX000_RS03905 794809..795579 + 771 WP_002451621.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T194842 WP_002451625.1 NZ_CP070964:792242-792604 [Staphylococcus sp. SB1-57]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp

>T194842 NZ_CP094119:c1392572-1392291 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTACAAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCGCTCCAACAAAAGTATTGCGACCATGCCTTAAGTGGCAATC
TTAAAGGGTTGAGAGAGTGCCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT194842 WP_002451626.1 NZ_CP070964:792075-792245 [Staphylococcus sp. SB1-57]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT194842 NZ_CP094119:c1392879-1392565 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAACAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATAGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PXE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References