Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 122690..123249 | Replicon | plasmid pMG101_B |
| Accession | NZ_CP070963 | ||
| Organism | Escherichia coli strain K-12 J53 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | V0SVC8 |
| Locus tag | JTR57_RS23110 | Protein ID | WP_000421272.1 |
| Coordinates | 122690..122965 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0SRR3 |
| Locus tag | JTR57_RS23115 | Protein ID | WP_001387467.1 |
| Coordinates | 122965..123249 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JTR57_RS23080 (118740) | 118740..119480 | - | 741 | WP_001066953.1 | tyrosine-type recombinase/integrase | - |
| JTR57_RS23085 (119601) | 119601..119783 | - | 183 | WP_042344623.1 | hypothetical protein | - |
| JTR57_RS23440 (119850) | 119850..120139 | - | 290 | Protein_135 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| JTR57_RS23090 (120126) | 120126..120394 | - | 269 | Protein_136 | type II toxin-antitoxin system ParD family antitoxin | - |
| JTR57_RS23095 (120926) | 120926..122095 | + | 1170 | WP_001072355.1 | hypothetical protein | - |
| JTR57_RS23100 (122128) | 122128..122256 | + | 129 | Protein_138 | IS481 family transposase | - |
| JTR57_RS23105 (122381) | 122381..122584 | - | 204 | Protein_139 | hypothetical protein | - |
| JTR57_RS23110 (122690) | 122690..122965 | - | 276 | WP_000421272.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JTR57_RS23115 (122965) | 122965..123249 | - | 285 | WP_001387467.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| JTR57_RS23120 (123854) | 123854..124606 | + | 753 | WP_000562172.1 | IclR family transcriptional regulator | - |
| JTR57_RS23125 (124652) | 124652..125617 | - | 966 | WP_001022265.1 | 2-keto-3-deoxygluconate transporter | - |
| JTR57_RS23130 (125650) | 125650..126030 | - | 381 | WP_000710783.1 | Rid family detoxifying hydrolase | - |
| JTR57_RS23135 (126055) | 126055..126945 | - | 891 | WP_001077068.1 | dihydrodipicolinate synthase family protein | - |
| JTR57_RS23140 (127178) | 127178..127372 | - | 195 | WP_000796505.1 | hypothetical protein | - |
| JTR57_RS23145 (127346) | 127346..127786 | + | 441 | Protein_147 | zinc-binding dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul1 / qacE / ant(3'')-Ia / blaOXA-1 / sitABCD / tet(B) / catA1 | iutA / iucD / iucC / iucB / iucA | 1..154497 | 154497 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10749.45 Da Isoelectric Point: 10.0871
>T194839 WP_000421272.1 NZ_CP070963:c122965-122690 [Escherichia coli]
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T194839 NZ_CP094116:575130-575471 [Helicobacter pylori]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAACTTATTAAAAACGGATTTGATGATAGCGTTTT
GAATAAGGTCATTCTATCTTTGAGAAAGAAAGAACCACTAGATCTCCAATTTCAAGATCATGCTTTGAAAGGAAAGTGGA
AACCTTTTAGGGAATGCCATATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGGTGATGAGCTTATTTTAGTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTGTAAATCACCCGCACAACTTATAACGCTTGAACTGACTGCTTCACCAACTACCCC
CCTTTTTAGGGATAAAATTTAG
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAACTTATTAAAAACGGATTTGATGATAGCGTTTT
GAATAAGGTCATTCTATCTTTGAGAAAGAAAGAACCACTAGATCTCCAATTTCAAGATCATGCTTTGAAAGGAAAGTGGA
AACCTTTTAGGGAATGCCATATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGGTGATGAGCTTATTTTAGTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTGTAAATCACCCGCACAACTTATAACGCTTGAACTGACTGCTTCACCAACTACCCC
CCTTTTTAGGGATAAAATTTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10460.87 Da Isoelectric Point: 5.6558
>AT194839 WP_001387467.1 NZ_CP070963:c123249-122965 [Escherichia coli]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
Download Length: 285 bp
>AT194839 NZ_CP094116:574772-575143 [Helicobacter pylori]
ATGCCTAATTCTCCCGCCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGGTGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGTGAAAACTTAGAAACTATTGAAGA
CCTTTCTGCATGGGCAAATGAAGTGAAAAAGGAAGTGAATGCTGAAAATTAA
ATGCCTAATTCTCCCGCCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGGTGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGTGAAAACTTAGAAACTATTGAAGA
CCTTTCTGCATGGGCAAATGAAGTGAAAAAGGAAGTGAATGCTGAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0SVC8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y880 |