Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3733816..3734411 Replicon chromosome
Accession NZ_CP070962
Organism Escherichia coli strain K-12 J53

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag JTR57_RS18260 Protein ID WP_000239577.1
Coordinates 3733816..3734166 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag JTR57_RS18265 Protein ID WP_001223208.1
Coordinates 3734160..3734411 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTR57_RS18240 (3729262) 3729262..3730284 - 1023 WP_001313531.1 ABC transporter permease -
JTR57_RS18245 (3730298) 3730298..3731800 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
JTR57_RS18250 (3731940) 3731940..3732896 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JTR57_RS18255 (3733206) 3733206..3733736 + 531 WP_000055075.1 inorganic diphosphatase -
JTR57_RS18260 (3733816) 3733816..3734166 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
JTR57_RS18265 (3734160) 3734160..3734411 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JTR57_RS18270 (3734623) 3734623..3734964 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JTR57_RS18275 (3734967) 3734967..3738746 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T194825 WP_000239577.1 NZ_CP070962:c3734166-3733816 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T194825 NZ_CP094101:576149-576415 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGACGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCCCAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAACCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTAGTAAGA
CTAGGCAGCCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT194825 WP_001223208.1 NZ_CP070962:c3734411-3734160 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT194825 NZ_CP094101:575791-576168 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTGCACACAATACAGCGAAAAACAGCTTTTTAACTTAATCCATCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGGACTCTTGCAAAAAATCAGCCAAGCTTTTGATAATAAAAGAGATTGCTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References