Detailed information of TA system TA194824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3647606..3648420
• Replicon: chromosome
• Accession: NZ_CP070962
• Organism: Escherichia coli strain K-12 J53

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: JTR57_RS17820
• Protein ID: WP_001054376.1
• Coordinates: 3647606..3647863 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: JTR57_RS17825
• Protein ID: WP_001309181.1
• Coordinates: 3647875..3648420 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTR57_RS17800 (3642894)	3642894..3644000	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
JTR57_RS17805 (3644065)	3644065..3645045	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
JTR57_RS23385 (3645155)	3645155..3645360	+	206	Protein_3500	HNH endonuclease	-
JTR57_RS17810 (3645628)	3645628..3646868	-	1241	Protein_3501	helicase YjhR	-
JTR57_RS23390 (3646984)	3646984..3647115	+	132	WP_001309182.1	hypothetical protein	-
JTR57_RS17820 (3647606)	3647606..3647863	+	258	WP_001054376.1	YjhX family toxin	Toxin
JTR57_RS17825 (3647875)	3647875..3648420	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
JTR57_RS17830 (3648476)	3648476..3649222	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
JTR57_RS17835 (3649391)	3649391..3649609	+	219	Protein_3506	hypothetical protein	-
JTR57_RS17840 (3649647)	3649647..3649763	+	117	Protein_3507	VOC family protein	-
JTR57_RS17845 (3650008)	3650008..3651129	+	1122	WP_000010829.1	M42 family metallopeptidase	-
JTR57_RS17850 (3651126)	3651126..3651404	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
JTR57_RS17855 (3651416)	3651416..3652729	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	3637392..3656644	19252

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T194824 WP_001054376.1 NZ_CP070962:3647606-3647863 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T194824 NZ_CP094099:578775-579041 [Helicobacter pylori]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAACTTATTAAAAACGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTAGACCCACAATTTAAAGATCACGCTTTAAAAGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTACTTGTTTATTTAGTGAAAGATGATGAGCTTATTTTGTTAAGG
TTAGGTAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT194824 WP_001309181.1 NZ_CP070962:3647875-3648420 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT194824 NZ_CP094099:578417-578788 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACGCAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCATTAAATGGCGAGAACTTAGAAACTATTGAAGA
CTTTTCTGCATGGGCAAATGAAGTGAAAAAGGAAGTGAATGCTGAAAATTAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8