Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3071258..3071876 | Replicon | chromosome |
Accession | NZ_CP070962 | ||
Organism | Escherichia coli strain K-12 J53 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | JTR57_RS15065 | Protein ID | WP_001291435.1 |
Coordinates | 3071658..3071876 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | JTR57_RS15060 | Protein ID | WP_000344800.1 |
Coordinates | 3071258..3071632 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JTR57_RS15050 (3066347) | 3066347..3067540 | + | 1194 | WP_001295324.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
JTR57_RS15055 (3067563) | 3067563..3070712 | + | 3150 | WP_001132469.1 | efflux RND transporter permease AcrB | - |
JTR57_RS15060 (3071258) | 3071258..3071632 | + | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
JTR57_RS15065 (3071658) | 3071658..3071876 | + | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
JTR57_RS15070 (3072048) | 3072048..3072599 | + | 552 | WP_000102564.1 | maltose O-acetyltransferase | - |
JTR57_RS15075 (3072715) | 3072715..3073185 | + | 471 | WP_000136192.1 | YlaC family protein | - |
JTR57_RS15080 (3073349) | 3073349..3074899 | + | 1551 | WP_001310610.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
JTR57_RS15085 (3074941) | 3074941..3075294 | - | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
JTR57_RS15095 (3075673) | 3075673..3075984 | + | 312 | WP_000409911.1 | MGMT family protein | - |
JTR57_RS15100 (3076015) | 3076015..3076587 | - | 573 | WP_000779842.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T194819 WP_001291435.1 NZ_CP070962:3071658-3071876 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T194819 NZ_CP094094:c1069100-1068891 [Helicobacter pylori]
ATGCTGATGATTGAAACCAATAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGCTCCCAAATACAAAGACCACCCTCTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACTTAAAAAACAAGAAAACACCCTCTTTTTAG
ATGCTGATGATTGAAACCAATAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGCTCCCAAATACAAAGACCACCCTCTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACTTAAAAAACAAGAAAACACCCTCTTTTTAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT194819 WP_000344800.1 NZ_CP070962:3071258-3071632 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT194819 NZ_CP094094:c1069398-1069087 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATTAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAACATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA
ATGCCTAATTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATTAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAACATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |