194807

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1485620..1486451 Replicon chromosome
Accession NZ_CP070962
Organism Escherichia coli strain K-12 J53

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JTR57_RS07125 Protein ID WP_000854814.1
Coordinates 1485620..1485994 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag JTR57_RS07130 Protein ID WP_001285584.1
Coordinates 1486083..1486451 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTR57_RS07085 (1481016) 1481016..1482182 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JTR57_RS07090 (1482301) 1482301..1482774 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
JTR57_RS07095 (1482972) 1482972..1484030 + 1059 WP_001200891.1 FUSC family protein -
JTR57_RS07100 (1484202) 1484202..1484531 + 330 WP_000450409.1 DUF496 family protein -
JTR57_RS07105 (1484632) 1484632..1484766 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
JTR57_RS07110 (1484886) 1484886..1485014 + 129 Protein_1393 transposase domain-containing protein -
JTR57_RS07115 (1485303) 1485303..1485383 - 81 Protein_1394 hypothetical protein -
JTR57_RS07120 (1485429) 1485429..1485623 - 195 WP_000988600.1 DUF5983 family protein -
JTR57_RS07125 (1485620) 1485620..1485994 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
JTR57_RS07130 (1486083) 1486083..1486451 - 369 WP_001285584.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JTR57_RS07135 (1486525) 1486525..1486746 - 222 WP_000692323.1 DUF987 domain-containing protein -
JTR57_RS07140 (1486809) 1486809..1487255 - 447 WP_000187523.1 RadC family protein -
JTR57_RS07145 (1487252) 1487252..1488784 - 1533 WP_001350525.1 protein YeeR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T194807 WP_000854814.1 NZ_CP070962:c1485994-1485620 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T194807 NZ_CP094085:18480-19241 [Helicobacter pylori]
ATGGAAATTAAAGAAGAGGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGCTGTGCGAAGAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATAAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACGCTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATATTTCTATAAGGTTAGATAATCTAAATAAAAACTATAAAAAATTAA
GCGAAGAATTGAATAAGCAACAAACACAATACATAACAATTCTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTTGGG
GGATTGGCGTTTTCTACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTTTAT
AGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGGAAAGAGATA
AACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTACAATTCTATTTGTGATTGGTTTTTTTGGA
GAATTGCATATAATACAAAGATTAGTTTCTAAATATCTTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT194807 WP_001285584.1 NZ_CP070962:c1486451-1486083 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT194807 NZ_CP094085:18053-18490 [Helicobacter pylori]
ATGGTCAATACTTTGGAATTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCGCAAAATCTTAGAAAAGATGAATTGGAAACCATCAATCGCTCCATAGAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2E8G6

References