Detailed information of TA system TA194797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2369007..2369526
• Replicon: chromosome
• Accession: NZ_CP070959
• Organism: Thiomicrospira microaerophila strain BDL05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JX580_RS11550
• Protein ID: WP_248850690.1
• Coordinates: 2369007..2369297 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JX580_RS11555
• Protein ID: WP_248850691.1
• Coordinates: 2369287..2369526 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JX580_RS11535 (JX580_11550)	2365709..2368021	-	2313	WP_248850687.1	DEAD/DEAH box helicase family protein	-
JX580_RS11540 (JX580_11555)	2368103..2368552	-	450	WP_248850688.1	hypothetical protein	-
JX580_RS11545 (JX580_11560)	2368562..2368939	-	378	WP_248850689.1	P-II family nitrogen regulator	-
JX580_RS11550 (JX580_11565)	2369007..2369297	-	291	WP_248850690.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JX580_RS11555 (JX580_11570)	2369287..2369526	-	240	WP_248850691.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JX580_RS11560 (JX580_11575)	2369654..2371378	-	1725	WP_248850692.1	DUF1538 domain-containing protein	-
JX580_RS11565 (JX580_11580)	2371392..2372894	-	1503	WP_248850693.1	DUF1538 domain-containing protein	-
JX580_RS11570 (JX580_11585)	2372901..2373302	-	402	WP_248850694.1	CBS domain-containing protein	-
JX580_RS11575 (JX580_11590)	2373302..2373652	-	351	WP_248850695.1	hypothetical protein	-
JX580_RS11580 (JX580_11595)	2374081..2374359	+	279	WP_248850696.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-55)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11402.28 Da
• Isoelectric Point: 10.3015

>T194797 WP_248850690.1 NZ_CP070959:c2369297-2369007 [Thiomicrospira microaerophila]
MTYNLEFDERALKEWKQLDGSIRSQLKKKLEQVIENPIVKKNALRELDNCYKIKLRQSGYRLIYQVQDARVVVFVIAIGK
RDKEQAYRDATVRIKS

Nucleotide

• Length: 291 bp

>T194797 NZ_CP094074:573663-573929 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTAAGAAAAAAAGAACCGCTAGATCCACAATTTAAAGATCATGCTTTAAGGGGAAAGTGGA
AACTTTTTAGGGAATGCCACATTAAACCTGATATTTTGCTTGTGTATTTGGTGAAAGATGATGAGCTTATTTTAGTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9023.27 Da
• Isoelectric Point: 4.3313

>AT194797 WP_248850691.1 NZ_CP070959:c2369526-2369287 [Thiomicrospira microaerophila]
MGTITIRVDDELKSEAYQALENLNITPSELLRQTLKYVAQNHKLPFKPALLSEEDFDLLETVRERLNDPKPVAVSLDDL

Nucleotide

• Length: 240 bp

>AT194797 NZ_CP094074:573305-573682 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACGCAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATAATAAAAGAGATTATTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGTGCTTAACAAAGAAACCGATTTGATTGTTGATGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAAGGCGTTAGGTGTTGAAACTCAACCTTAA