Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2313950..2314598 Replicon chromosome
Accession NZ_CP070959
Organism Thiomicrospira microaerophila strain BDL05

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag JX580_RS11250 Protein ID WP_248850635.1
Coordinates 2314176..2314598 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag JX580_RS11245 Protein ID WP_248850634.1
Coordinates 2313950..2314183 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JX580_RS11235 (JX580_11250) 2309548..2311185 + 1638 WP_248850632.1 BatD family protein -
JX580_RS11240 (JX580_11255) 2311234..2313732 - 2499 WP_248850633.1 methyl-accepting chemotaxis protein -
JX580_RS11245 (JX580_11260) 2313950..2314183 + 234 WP_248850634.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JX580_RS11250 (JX580_11265) 2314176..2314598 + 423 WP_248850635.1 type II toxin-antitoxin system VapC family toxin Toxin
JX580_RS11255 (JX580_11270) 2314660..2315232 - 573 WP_248850636.1 cupredoxin family protein -
JX580_RS11260 (JX580_11275) 2315264..2316106 - 843 WP_248850637.1 copper resistance protein B -
JX580_RS11265 (JX580_11280) 2316240..2318114 - 1875 WP_248850638.1 copper resistance system multicopper oxidase -
JX580_RS11270 (JX580_11285) 2318344..2318586 + 243 WP_248850639.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JX580_RS11275 (JX580_11290) 2318591..2318854 + 264 WP_248850640.1 Txe/YoeB family addiction module toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15673.29 Da        Isoelectric Point: 7.0382

>T194796 WP_248850635.1 NZ_CP070959:2314176-2314598 [Thiomicrospira microaerophila]
MSKKIDYMLDTCICSFIMREQPYCVLEKLQAAVMNGHRVVISAITYQEIHYGLLGKKASPKHALLVAEFLKRIDEILAWD
KQAVDATVIVQKQLMAEGLMIGHNDTAIAGHAISTGSILVTNNTREFARVNGLTFEDWVH

Download         Length: 423 bp

>T194796 NZ_CP094073:c1547187-1546906 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAACATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTACAAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCGCTCCAACAAAAGTATTGCGACCATGCCTTAAGTGGCAATC
TTAAAGGGTTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTATT
TTATTGCGTCTAGACACTCACAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9150.42 Da        Isoelectric Point: 4.6437

>AT194796 WP_248850634.1 NZ_CP070959:2313950-2314183 [Thiomicrospira microaerophila]
MRTVSIFKNAKNQAIRLPKDMEYEGISQLEIIKNGDEIILRPVRPNWLSFSEIEKADDDFMLERQRFVADEGRFNFE

Download         Length: 234 bp

>AT194796 NZ_CP094073:c1547494-1547180 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATAAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAAGAGATAAAAATAAAGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTGAATACAATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References