Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 2228806..2229326 Replicon chromosome
Accession NZ_CP070959
Organism Thiomicrospira microaerophila strain BDL05

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag JX580_RS10845 Protein ID WP_248850556.1
Coordinates 2229036..2229326 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag JX580_RS10840 Protein ID WP_248850555.1
Coordinates 2228806..2229039 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JX580_RS10820 (JX580_10840) 2226352..2226747 - 396 WP_248850551.1 response regulator -
JX580_RS10825 (JX580_10845) 2226762..2227844 - 1083 WP_248850552.1 response regulator -
JX580_RS10830 (JX580_10850) 2228097..2228345 + 249 WP_248850553.1 hypothetical protein -
JX580_RS10835 (JX580_10855) 2228366..2228692 + 327 WP_248850554.1 type II toxin-antitoxin system PemK/MazF family toxin -
JX580_RS10840 (JX580_10860) 2228806..2229039 + 234 WP_248850555.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JX580_RS10845 (JX580_10865) 2229036..2229326 + 291 WP_248850556.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JX580_RS10850 (JX580_10870) 2229950..2231827 + 1878 WP_248850557.1 phosphomethylpyrimidine synthase ThiC -
JX580_RS10855 (JX580_10875) 2231831..2232868 + 1038 WP_248850558.1 FAD-dependent oxidoreductase -
JX580_RS10860 (JX580_10880) 2233086..2233280 + 195 WP_248850559.1 sulfur carrier protein ThiS -
JX580_RS10865 (JX580_10885) 2233498..2234298 + 801 WP_248851925.1 thiazole synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Antitoxin ParD

(6-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11330.95 Da        Isoelectric Point: 8.9074

>T194795 WP_248850556.1 NZ_CP070959:2229036-2229326 [Thiomicrospira microaerophila]
MKIEFKPKAQQDLSDIWDYTCQQWGTVQAETYIRNIWQTIESLKSSYNPSQNIDFVRAGYRKIQSGSHVIFFKQALDTIT
VIRILHQQMDITKHLP

Download         Length: 291 bp

>T194795 NZ_CP094071:613676-613888 [Helicobacter pylori]
TTGAATGGGTTTGATGATAGCGTTTTGAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCA
AGATCATGCTTTAAAGGGAAAGTGGAAACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTGGTGA
AAGATGATGAGCTTATTTTAGTAAGACTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8692.83 Da        Isoelectric Point: 4.6855

>AT194795 WP_248850555.1 NZ_CP070959:2228806-2229039 [Thiomicrospira microaerophila]
MMATMNISLPDQMKNWVEESVQSGLYANASDYVRDLIRQDHQKMAALRQALIEGEKSGVASEFDLETFINAKKQTAQ

Download         Length: 234 bp

>AT194795 NZ_CP094071:613264-613641 [Helicobacter pylori]
ATGCCAAACACCACCGCCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGACAAAAGGGATCAAAACT
TTAAGGATAAAATAGATGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATAATAAAAGAGATTGTTGTTTG
GGGTATGAGATCCCAAACATTGAAACGCAACAAGCCATGAGAGATGCGTTAAACAAAGAAACCGATTTGATTGTTGAGGA
TTTCTCTAGTTATAGCGATGAAAGAAAAAAGGCACTAGGTGTTAAAACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References