Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1964441..1965917 Replicon chromosome
Accession NZ_CP070959
Organism Thiomicrospira microaerophila strain BDL05

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag JX580_RS09470 Protein ID WP_248850303.1
Coordinates 1964441..1965643 (-) Length 401 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag JX580_RS09475 Protein ID WP_248850304.1
Coordinates 1965660..1965917 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JX580_RS09440 (JX580_09455) 1959667..1959981 - 315 WP_248850297.1 type II toxin-antitoxin system RelE/ParE family toxin -
JX580_RS09445 (JX580_09460) 1959974..1960234 - 261 WP_248850298.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JX580_RS09450 (JX580_09465) 1960499..1962655 + 2157 WP_248850299.1 catalase/peroxidase HPI -
JX580_RS09455 (JX580_09470) 1962793..1962993 + 201 WP_248850300.1 hypothetical protein -
JX580_RS09460 (JX580_09475) 1962959..1963303 + 345 WP_248850301.1 type II toxin-antitoxin system PemK/MazF family toxin -
JX580_RS09465 (JX580_09480) 1963329..1964375 - 1047 WP_248850302.1 AI-2E family transporter -
JX580_RS09470 (JX580_09485) 1964441..1965643 - 1203 WP_248850303.1 type II toxin-antitoxin system HipA family toxin Toxin
JX580_RS09475 (JX580_09490) 1965660..1965917 - 258 WP_248850304.1 helix-turn-helix transcriptional regulator Antitoxin
JX580_RS09480 (JX580_09495) 1966080..1966880 + 801 WP_248850305.1 TOBE domain-containing protein -
JX580_RS09485 (JX580_09500) 1966984..1967748 + 765 WP_248850306.1 molybdate ABC transporter substrate-binding protein -
JX580_RS09490 (JX580_09505) 1967782..1968477 + 696 WP_248850307.1 molybdate ABC transporter permease subunit -
JX580_RS09495 (JX580_09510) 1968482..1969558 + 1077 WP_248850308.1 molybdenum ABC transporter ATP-binding protein -
JX580_RS09500 (JX580_09515) 1969563..1970360 + 798 WP_248850309.1 sulfite exporter TauE/SafE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(26-78)


Sequences

Toxin        


Download         Length: 401 a.a.        Molecular weight: 44953.89 Da        Isoelectric Point: 7.9760

>T194794 WP_248850303.1 NZ_CP070959:c1965643-1964441 [Thiomicrospira microaerophila]
VQQLYVFYQQSRVGELVKLNARQMRFKYDQAWLANPNAFALSISLPLRSEPFEQAETFFANLLPEADVRAALCKKLGLSE
KNDFGLLAEIGGDVAGAISIYSTLQLPVYESQFLPLSESSLAELLQALEKNPFKAIDGDIRLSLAGAQNKLPVMKLDKAS
SPFALPISPDLATTHIIKLANTHFKDLVLNEVTTMRLAKALGLNVPEVDFLSVAGKTHFIIQRYDRSNGERLHQEDFCQA
LAIDAANKYEAEGGPSLKECADLIRGYSHKPAADLLQFVRWVLFNLLVGNCDAHGKNIAFLYAPKCELAPFYDLISTQCY
ETLSQKFSMKIGGENRLDWIQKRHLQAFSESIGVKFTFVLKEFNKMVALIEQHQSVLESYLPLKRVVNNNVQKFSRRFKV

Download         Length: 1203 bp

>T194794 NZ_CP094071:351154-351435 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTACAAGCATTGTTGATTGCCTCAAAGAGCAAAAACCACTCCAACAAAAGTATTGCGACCATGCCTTGAGCGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9068.54 Da        Isoelectric Point: 10.0184

>AT194794 WP_248850304.1 NZ_CP070959:c1965917-1965660 [Thiomicrospira microaerophila]
MTNVKNIPNGNIEGLHNPILDSVQLGNKVRDKRKKDGLTQQDLAAVAGVGVRFVSELENGKPSVQLNTVLAVLAALGLQL
LIVDK

Download         Length: 258 bp

>AT194794 NZ_CP094071:350847-351161 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTATTCGCAATACAATGAAAAGCAACTGCACAATTTTTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAACACGATCGTCTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATAATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References