Detailed information of TA system TA194792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-VagC
• Location: 1244795..1245432
• Replicon: chromosome
• Accession: NZ_CP070959
• Organism: Thiomicrospira microaerophila strain BDL05

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JX580_RS06095
• Protein ID: WP_248849670.1
• Coordinates: 1244795..1245211 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: -
• Locus tag: JX580_RS06100
• Protein ID: WP_248849671.1
• Coordinates: 1245208..1245432 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JX580_RS06070 (JX580_06075)	1240360..1241736	-	1377	WP_248849665.1	DNA recombination protein RmuC	-
JX580_RS06075 (JX580_06080)	1241742..1242698	-	957	WP_248849666.1	cation transporter	-
JX580_RS06080 (JX580_06085)	1242714..1243133	-	420	WP_248849667.1	CopD family protein	-
JX580_RS06085 (JX580_06090)	1243233..1243715	+	483	WP_248849668.1	peptidylprolyl isomerase	-
JX580_RS06090 (JX580_06095)	1243792..1244727	-	936	WP_248849669.1	ribosome biogenesis GTPase YlqF	-
JX580_RS06095 (JX580_06100)	1244795..1245211	-	417	WP_248849670.1	type II toxin-antitoxin system VapC family toxin	Toxin
JX580_RS06100 (JX580_06105)	1245208..1245432	-	225	WP_248849671.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JX580_RS06105 (JX580_06110)	1245539..1245976	-	438	WP_248849672.1	YcgN family cysteine cluster protein	-
JX580_RS06110 (JX580_06115)	1245976..1246644	-	669	WP_248849673.1	TIGR01621 family pseudouridine synthase	-
JX580_RS06115 (JX580_06120)	1246641..1247723	-	1083	WP_248849674.1	DNA alkylation repair protein	-
JX580_RS06120 (JX580_06125)	1247799..1248254	+	456	WP_248849675.1	hypothetical protein	-
JX580_RS06125 (JX580_06130)	1248251..1249555	-	1305	WP_248849676.1	TlpA disulfide reductase family protein	-
JX580_RS06130 (JX580_06135)	1249561..1250217	-	657	WP_248849677.1	CBS domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• SpoVT-AbrB domain (6-41)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15756.11 Da
• Isoelectric Point: 5.9066

>T194792 WP_248849670.1 NZ_CP070959:c1245211-1244795 [Thiomicrospira microaerophila]
MKYLLDTCALSELTKTQTNPGFLSWFEAQNGDDFYISVITLAEIEKGIQRLADSKKKRHLNDWLERIEVGFAERSKVFDI
PLAKTWAKMTAMSESQGRRLPSFDSIIAATALKYDLVLVTRNEQDFIGLPIQVLNPWS

Nucleotide

• Length: 417 bp

>T194792 NZ_CP094070:c1096605-1096339 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGACGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCCCAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAACCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTAGTAAGA
CTAGGCAGCCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8544.82 Da
• Isoelectric Point: 6.3276

>AT194792 WP_248849671.1 NZ_CP070959:c1245432-1245208 [Thiomicrospira microaerophila]
MEAKIFQSGNSQAVRIPKEFRFNVTTVEIFKRGDEVVLKPKTTDLKSLLLSAPKVDFDVERDRFDLVPDRVSFE

Nucleotide

• Length: 225 bp

>AT194792 NZ_CP094070:c1096963-1096586 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTGCACACAATACAGCGAAAAACAGCTTTTTAACTTAATCCATCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGGACTCTTGCAAAAAATCAGCCAAGCTTTTGATAATAAAAGAGATTGCTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA