Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1225309..1226048 Replicon chromosome
Accession NZ_CP070959
Organism Thiomicrospira microaerophila strain BDL05

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag JX580_RS05965 Protein ID WP_248849625.1
Coordinates 1225309..1225794 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag JX580_RS05970 Protein ID WP_248849628.1
Coordinates 1225782..1226048 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JX580_RS05950 (JX580_05955) 1220752..1224687 - 3936 WP_248851868.1 ATP-dependent RNA helicase HrpA -
JX580_RS05955 (JX580_05960) 1224694..1224960 - 267 WP_248849620.1 type II toxin-antitoxin system RelE/ParE family toxin -
JX580_RS05960 (JX580_05965) 1224944..1225168 - 225 WP_248849623.1 TraY domain-containing protein -
JX580_RS05965 (JX580_05970) 1225309..1225794 - 486 WP_248849625.1 GNAT family N-acetyltransferase Toxin
JX580_RS05970 (JX580_05975) 1225782..1226048 - 267 WP_248849628.1 DUF1778 domain-containing protein Antitoxin
JX580_RS05975 (JX580_05980) 1226114..1226368 - 255 WP_248849630.1 Txe/YoeB family addiction module toxin -
JX580_RS05980 (JX580_05985) 1226359..1226616 - 258 WP_248849635.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
JX580_RS05985 (JX580_05990) 1226712..1227017 - 306 WP_248849636.1 nucleotidyltransferase domain-containing protein -
JX580_RS05990 (JX580_05995) 1227014..1227490 - 477 WP_248849638.1 hypothetical protein -
JX580_RS05995 (JX580_06000) 1227487..1228020 - 534 WP_248849640.1 DUF3087 family protein -
JX580_RS06000 (JX580_06005) 1228029..1228454 - 426 WP_248849642.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
JX580_RS06005 (JX580_06010) 1228520..1229215 + 696 WP_248849644.1 DNA polymerase III subunit epsilon -
JX580_RS06010 (JX580_06015) 1229269..1229706 - 438 WP_248849646.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17813.67 Da        Isoelectric Point: 8.8268

>T194789 WP_248849625.1 NZ_CP070959:c1225794-1225309 [Thiomicrospira microaerophila]
MASLISAPAVLSDQHDLGSFCCGHDRLDYWLKREAMRNQKNHGSKTFVITCADQVVGYYALAAGSVERQEVSKTNARNMP
DTIPVIMLGRLAMDKTMQGKALLKDALFRSLNVANEIAVKAALVHAIYDQACRFYQNFGFKPLPGTERTLMLPISHIQAA
L

Download         Length: 486 bp

>T194789 NZ_CP094067:18525-19322 [Helicobacter pylori]
ATGGAAATTAAAGAAGAGGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGCTGTGCGAAGAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATAAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACGCTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATATTTCTATAAGGTTAGATAATCTAAATAAAAACTATAAAAAATTAA
GTGAAGAATTGAATAAGCAACAAACACAATACATAACAATTCTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTTGGG
GGATTGGCGTTTTCTACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTATTATGGCTTTTAT
AGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCATCAAAAATATCCTTAT
CAAAAGAGGAAAGAGATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTATAATTCTATTT
GTGATTGGTTTTGTGGGAGAGAGAATTGATAGGCAATATAAAGCTCAGATTTCTAAAGATTTTAAAAGACCAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9897.65 Da        Isoelectric Point: 7.9813

>AT194789 WP_248849628.1 NZ_CP070959:c1226048-1225782 [Thiomicrospira microaerophila]
MLAKAPINMRVLPEQKALISKAAEILSMDRTTFILNVACREAENVLLDQRLFLLNQNDYNAFETALMATPKPNALLKKLL
SEPSPWQA

Download         Length: 267 bp

>AT194789 NZ_CP094067:18098-18535 [Helicobacter pylori]
ATGGTCAATACTTTGGAATTAGCAAAATATATTCTTAAGCATTCCAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTTCAAGAGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCTATTGACAAACCTAAAGAAGAAACGCTC
TCACAAGATCTTAGAGAAGATGAACTTGAAACCATCAATCGCTCCATAGAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References