Detailed information of TA system TA194787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 1224694..1225168
• Replicon: chromosome
• Accession: NZ_CP070959
• Organism: Thiomicrospira microaerophila strain BDL05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JX580_RS05955
• Protein ID: WP_248849620.1
• Coordinates: 1224694..1224960 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: JX580_RS05960
• Protein ID: WP_248849623.1
• Coordinates: 1224944..1225168 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JX580_RS05945	1220260..1220718	-	459	WP_248851867.1	cytochrome c	-
JX580_RS05950 (JX580_05955)	1220752..1224687	-	3936	WP_248851868.1	ATP-dependent RNA helicase HrpA	-
JX580_RS05955 (JX580_05960)	1224694..1224960	-	267	WP_248849620.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JX580_RS05960 (JX580_05965)	1224944..1225168	-	225	WP_248849623.1	TraY domain-containing protein	Antitoxin
JX580_RS05965 (JX580_05970)	1225309..1225794	-	486	WP_248849625.1	GNAT family N-acetyltransferase	-
JX580_RS05970 (JX580_05975)	1225782..1226048	-	267	WP_248849628.1	DUF1778 domain-containing protein	-
JX580_RS05975 (JX580_05980)	1226114..1226368	-	255	WP_248849630.1	Txe/YoeB family addiction module toxin	-
JX580_RS05980 (JX580_05985)	1226359..1226616	-	258	WP_248849635.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
JX580_RS05985 (JX580_05990)	1226712..1227017	-	306	WP_248849636.1	nucleotidyltransferase domain-containing protein	-
JX580_RS05990 (JX580_05995)	1227014..1227490	-	477	WP_248849638.1	hypothetical protein	-
JX580_RS05995 (JX580_06000)	1227487..1228020	-	534	WP_248849640.1	DUF3087 family protein	-
JX580_RS06000 (JX580_06005)	1228029..1228454	-	426	WP_248849642.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
JX580_RS06005 (JX580_06010)	1228520..1229215	+	696	WP_248849644.1	DNA polymerase III subunit epsilon	-
JX580_RS06010 (JX580_06015)	1229269..1229706	-	438	WP_248849646.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Relaxosome protein TraY (4-44)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10484.04 Da
• Isoelectric Point: 9.6578

>T194787 WP_248849620.1 NZ_CP070959:c1224960-1224694 [Thiomicrospira microaerophila]
MAWTIEYTDTSLKSLKKIDKTWQKRILDYLDNTVAVRDNPRDYGKPLVGHLSGLWRYRVGNYRVICQIQDQDLIILTTQI
SHRKDLYQ

Nucleotide

• Length: 267 bp

>T194787 NZ_CP094066:582474-582758 [Helicobacter pylori]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCTTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8470.54 Da
• Isoelectric Point: 5.0878

>AT194787 WP_248849623.1 NZ_CP070959:c1225168-1224944 [Thiomicrospira microaerophila]
MLAVRLDAEMEQELDRLARETGRTKTFYVKEALAHYLADIKDYYDAQDVLNNVKLGKEKVHSSADVRNTLGLDN

Nucleotide

• Length: 225 bp

>AT194787 NZ_CP094066:582101-582493 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGACAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGGACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTAAATGGGGTTAATCTCACTCAAATTGATAG
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATGGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA